危重症患者抗生素相关性腹泻的临床分析

目的 探讨危重症患者抗生素相关性腹泻的发病率、发病因素，进一步探讨抗生素应用对腹泻严重程度的影响。方法 对我院CCU及综合科2年内77例抗生素相关性腹泻的危重症患者的临床资料进行回顾性分析。结果 高龄、原发病的严重程度、侵袭性操作增加、频繁更换抗生素等都是重要的诱发因素，意识障碍越重、抗生素更换越频繁，腹泻持续时间越长。结论 合理应用抗生素，尤其应避免由低级到高级频繁更换抗生素，可以降低危重症患者抗生素相关性腹泻的发生率及严重程度。

Antibiotic-related Diarrhea in Critical Patients: A Clinical Analysis

OBJECTIVE To investigate the incidence, relative factors of antibiotic-related diarrhea, and the problems in choosing antibiotic. METHODS To study the usage of antibiotic, incidence of antibiotic-related diarrhea in the critical care unit and emergency department in our hospital in last 2 years (from Jan 2000 to Dec 2002). RESULTS The duration and severity of diarrhea depended on the complicated disease of the patient, the state of consciousness, and especially the treatment methods in choosing antibiotic. Changing anibiotics frequently from weaker to stronger ones made the manifestation more complicated. CONCLUSIONS The incidence and severity of antibiotic-related diarrhea can be reduced by using antibiotic more rationally, especially by avoiding changing antibiotics frequently.