骨成纤维性纤维瘤的临床病理研究

目的 探讨骨成纤维性纤维瘤（ＤＦ）的临床病理特点、组织发生、临床误诊及复发因素。方法 收集１１例骨成纤维性纤维瘤病例，男６例，女５例，年龄１１￣４２。免疫组织化学ＡＢＣ法标记ＳＭａｃｔｉｎ，Ｄｅｓｍｉｎ，Ｖｉｍｅｎｔｉｎ，ＮＳＥ，Ｓ－１００蛋白，α－ＡＴ（α－平滑肌肌动蛋白）及Ｌｙｓｏｚｇｍｅ。结果 Ｖｉｍｅｎｔｉｎ阳性１１例，Ｄｅｓｍｉｎ阳性９例、弱阳性２例，ＳＭａｃｔｉｎ阳性１０例、弱阳性１例

Study of Clinical and Pathological Features of Desmoplastic Fibroma of Bone

Objective The pathological features of desmoplastic fibroma (DF) in bone and itspathogenesis, recurrence as well as the cause of misdiagnosis were analysed. Methods Eleven cases of DFwere studied, including 6 females and 5 males, with a range of 11 to 42 years. Immunohistochemical studieshave been used to evaluate the patterns of immunoreactivity of DF. Results lmmunohistochemical stains ofDF showed that 11 cases were positive for Vimentin, 9 cases were positive for Desmin (2 cases were slightpositive), 10 cases were positive for SMactin (1 case is slight positive). All were negative for NSE, S-100protein, a - AT, lysozyme. Three cases recured, 4 cases occured pathological fracture. Eleven cases DF werenot diagnosed before operation. Conclusions DF contains myofibroblasts, featuring both smooth musclecells and fibroblasts. Radiologically and clinically, DF is a typical, which is liable to recur and to be mis-diagnosed. The tumor without capsule invades along bone trabecula and Haversian system. As a result, theaggressive behavior of this tumor was closely related to its recurrence.