| 草酸钙肾结石患者肾乳头钙盐沉积特点及其形成机制 |
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| 引用本文： | 陈书尚,高小峰,丁德英,周铁,王林辉,许传亮,孙颖浩.草酸钙肾结石患者肾乳头钙盐沉积特点及其形成机制[J].第二军医大学学报,2009,30(1):19-23. |
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| 作者姓名： | 陈书尚 高小峰 丁德英 周铁 王林辉 许传亮 孙颖浩 |
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| 作者单位： | 1. 第二军医大学长海医院泌尿外科,上海,200433
2. 第二军医大学药学院分析测试中心,上海,200433 |
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| 摘 要： | 目的:分析草酸钙肾结石患者肾乳头钙盐沉积特点及其在肾结石形成中的作用,并探讨肾钙盐沉积的机制。方法: 选择21例行经皮肾取石术(PCNL)的草酸钙肾结石(采用傅立叶转换红外光谱法检测结石成分)患者,术中观察肾乳头钙斑情况;获取肾组织标本,行茜素红染色,显微镜下观察钙盐沉积特点;免疫组化检测骨桥蛋白、骨形成蛋白-2（BMP-2）和Ⅱ型胶原在肾结石患者肾组织的表达情况。另选7例非结石肾切除标本作为正常对照。结果:21例草酸钙肾结石患者均可见肾乳头钙斑;活检标本可见钙盐沉积于肾小管基底膜附近肾间质,并可向肾乳头黏膜延伸;当钙盐突破尿路上皮进入集合系统后,其上可见小结石生长。肾结石患者肾组织和正常肾组织均可见骨桥蛋白表达,未见BMP-2和Ⅱ型胶原明显表达。结论:肾乳头钙盐沉积是草酸钙肾结石形成的起始病灶之一;钙盐的形成可能并不是一种类似于动脉钙化的成骨性反应。
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| 关 键 词： | 肾结石 钙盐沉积 草酸钙 成骨性反应 骨桥蛋白 |
| 收稿时间： | 6/4/2008 12:00:00 AM |
| 修稿时间： | 9/26/2008 9:23:55 PM |
Renal papillary calcareous deposits in patients with calcium oxalate kidney stones: characteristics and formation mechanism |
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| CHEN Shu-shang,GAO Xiao-feng,DING De-ying,ZHOU Tie,WANG Lin-hui,XU Chuan-liang,SUN Ying-hao.Renal papillary calcareous deposits in patients with calcium oxalate kidney stones: characteristics and formation mechanism[J].Academic Journal of Second Military Medical University,2009,30(1):19-23. |
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| Authors: | CHEN Shu-shang GAO Xiao-feng DING De-ying ZHOU Tie WANG Lin-hui XU Chuan-liang SUN Ying-hao |
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| Institution: | 1.Department of Urology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China*2.Center of Drug Analysis and Testing,School of Pharmacy,Second Military Medical University,Shanghai 200433 |
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| Abstract: | Objective:To investigate the characteristics of renal papillary calcareous deposits and their role in the formation of calcium oxalate kidney stone,and to explore the formation mechanism of renal calcareous deposits.Methods:A total of 21 patients with calcium oxalate kidney stones were included in the present study.The components of the calculi were detected by Fourier-transform infrared spectroscopy.The calcific plaques were observed and the renal papilla biopsy specimens were obtained during PCNL.The spec... |
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| Keywords: | renal calculi calcareous deposit calcium oxalate osteoblastic reaction osteopontin |
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