Morphological study of somatic muscles in alimentary-toxic paroxysmal myoglobinuria

The development of acute focal metabolic lesions of somatic muscles is shown in alimentary-toxic paroxysmal myoglobinuria. Two principal universal reactions of striated muscles are traced in the genesis of this pathological process, namely, contracture damage and intracellular myocytolysis. The functional asynchronism and structural-metabolic heterogeneity of muscle fibers are reflected in the stagewise and typical heterogeneity of the morphological picture, which preserves the entire spectrum of stereotypical pathological reactions regardless of the severity of the illness. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N ^o 2, pp. 228–233, February, 1996 Presented by D. S. Sarkisov, Member of the Russian Academy of Medical Sciences