Growth-factor regulation of mdm-2 messenger-RNA expression |
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| Authors: | Fei Z Rizzo M Baserga R |
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| Affiliation: | THOMAS JEFFERSON UNIV,JEFFERSON CANC INST,PHILADELPHIA,PA 19107. IST REGINA ELENA,ONCOGENESI MOLEC LAB,ROME,ITALY. |
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| Abstract: | We have investigated the growth factor regulation of mdm-2 mRNA levels in mouse embryo fibroblasts, whose growth is controlled by platelet-derived growth factor (PDGF) and insulin-like growth factor I (IGF-I). We find that both growth factors up-regulate the expression of mdm-2 mRNA, independently of each other. |
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