早产患者血清粒细胞集落刺激因子的检测及其意义

目的探讨粒细胞集落刺激因子(G-CSF)与自发性早产的关系及其对预测早产的可能意义。方法采用ELISA-双抗体夹心法分别对28-34周、34-37周不同孕龄组早产妇女及正常妊娠妇女的血清G-CSF进行检测。结果孕28-34周早产妇女血清G-CSF水平较正常对照组妇女升高(P<0.05)。结论高水平的血清G-CSF与妊娠<34周发生的早产有关,检测妊娠妇女血清G-CSF水平对预测妊娠34周之前发生的早产有重要意义。

Detection of serum granulocyte colony-stimulating factor in women with preterm birth and its significance

Objective To investigate the relationship between granulocyte colony-stimulating factor(G-CSF) and spontaneous preterm birth for analyzing the significance of the G-CSF level in preterm prediction.Methods The G-CSF levels in the peripheral blood from the women with spontaneous preterm birth at 28-34 weeks' gestation,the women with spontaneous preterm birth at 34-37 weeks' gestation,and the control women with normal pregnancy were detected by enzyme-linked immunosorbent assay(ELISA)-sandwich method.Results Serum G-CSF levels of the women with spontaneous preterm birth at 28-34 weeks' gestation were higher than those of the control normal women(P < 0.05). Conclusion The high level of G-CSF is associated with spontaneous preterm birth before 34 weeks' gestation.Detection of serum G-CSF will have been of great value in preterm prediction of < 34 weeks' gestation.