RNA干扰在肿瘤治疗中的靶点研究 |
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引用本文: | 袁慎俊,陈涛. RNA干扰在肿瘤治疗中的靶点研究[J]. 海南医学, 2016, 0(1): 85-87. DOI: 10.3969/j.issn.1003-6350.2016.01.030 |
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作者姓名: | 袁慎俊 陈涛 |
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作者单位: | 三峡大学医学院,湖北 宜昌,443002 |
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摘 要: | RNA干扰是一种转录后基因沉默机制.通过RNA干扰技术可以特异性剔除或关闭特定基因的表达,进而为恶性肿瘤的治疗提供一种崭新的手段.本文就RNA干扰的机制、作用靶标及相关的临床应用做一综述.
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关 键 词: | RNA干扰 基因沉默 微小RNAs 长非编码RNAs 肿瘤治疗 |
Application of RNA interference in cancer therapy |
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Abstract: | RNA interference (RNAi) is a post-transcriptional gene silencing. With RNAi technique, we can spe-cially reject or shut off the expression of certain genes and thereby provide a new therapy for maligant tumors. In this pa-per, the mechanism of RNAi, the target and related clinical applications are reviewed. |
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Keywords: | RNAi Gene silencing miRNAs lncRNAs Cancer therapy |
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