The role of necrotic cell death in the pathogenesis of immune mediated nephropathies |
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| Authors: | Neelakshi R. Jog Roberto Caricchio |
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| Affiliation: | Rheumatology Section, Department of Medicine, Temple Autoimmunity Center, Temple University School of Medicine, Philadelphia, PA, USA |
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| Abstract: | Necrosis, an inflammatory form of cell death, has been considered to be an accidental death and/or cell death due to injury. However, the literature in the last decade has established that necrosis is a regulated form of cell death, and that inhibition of specific molecular pathways leading to necrosis can block it and reduce inflammation. Since necrotic lesions are observed in several immune mediated human pathologies, in this review we will discuss the impact that this form of programmed cellular demise has in the pathology of immune mediated nephropathies. |
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| Keywords: | ANT, adenine nucleotide translocator (ANT) ANCA, Anti-Neutrophil Cytoplasmic Antibodies AAV, ANCA-associated vasculitis CSS, Churg&ndash Strauss syndrome CypD, cyclophilin D FADD, Fas associated death domain adaptor protein GPA, granulomatosis with polyangiitis GBM, glomerular basement membrane GN, glomerulonephritis HSP, Henoch&ndash Schö nlein purpura HMGB1, High Mobility Group Box-1 iNOS, inducible nitric oxide synthase MGN, membranous Glomerulonephritis MAC, membrane attack complex MPA, microscopic polyangiitis MPTP, mitochondrial permeability transition pore NAD +, nicotinamide adenine dinucleotide [α3(IV)NC1, non-collagenous domain of alpha 3 chain of type IV collagen PAR, poly(ADP-ribose) polymers PARP-1, Poly (ADP-Ribose) Polymerase-1 ROS, reactive oxygen species RIP, Receptor Interacting Protein kinase RHIM, RIP homotypic interaction motifs TNFα, tumor necrosis factor alpha TNFR1, TNF receptor 1 TRADD, tumor necrosis factor receptor type 1-associated death domain protein VDAC, voltage-dependent anion channel |
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