| 儿童原发性肾病综合征脂联素与其他脂代谢相关因素的探讨 |
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| 引用本文： | 郝胜,何威逊,朱光华,田国力,吴滢. 儿童原发性肾病综合征脂联素与其他脂代谢相关因素的探讨[J]. 临床儿科杂志, 2011, 29(4). DOI: 10.3969/j.issn.1000-3606.2011.04.009 |
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| 作者姓名： | 郝胜 何威逊 朱光华 田国力 吴滢 |
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| 作者单位： | 上海市儿童医院,上海交通大学附属儿童医院肾脏风湿科,上海,200040 |
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| 摘 要： | 目的 初步探讨儿童原发性肾病综合征(PNS)脂联素(ADPN)的变化,了解ADPN与PNS其他脂代谢相关因素的联系.方法 对71例PNS急性期患儿、37例缓解期患儿和35例健康儿童的血浆、尿液ADPN浓度进行定量分析,并将急性期患儿分为激素敏感组59例和激素耐药组12例,测定急性期患儿的体质指数(BMI)、肾小球滤过率(GFR)、血清白蛋白(Alb)、肌酐(Cr)、补体C3、三酰甘油(TG)、胆固醇(Tch)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、脂蛋白aLP(a)、载脂蛋白A(apoA)、载脂蛋白B(apoB)以及24 h尿蛋白定量,并进行相关性分析.结果 急性组的血浆、尿ADPN(14.02 ± 3.44 μg/ml,4.71 ± 2.12 μg/ml)显著高于缓解期组(7.13 ± 5.07 μg/ml,2.50 ± 1.06 μg/ml)和正常对照组(7.17 ± 2.94 μg/ml,2.60 ± 1.06 μg/ml)(P ＜ 0.01).激素耐药组血浆、尿ADPN均显著高于激素敏感组(P ＜ 0.05).PNS急性期患儿血浆ADPN分别与尿ADPN、血清TG、Tch、LDL、LP(a)、apoB及24 h尿蛋白定量正相关(r ＝ 0.242 7 ～ 0.609 1,P均＜ 0.05),与血清Alb、HDL负相关(r ＝ -0.745 4、-0.489 7,P ＜ 0.01).结论 PNS患儿的血浆及尿液ADPN浓度明显升高.血浆和尿液ADPN浓度与其他脂代谢指标密切相关.
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| 关 键 词： | 脂联素 肾病综合征 脂代谢 儿童 |
Adiponectin and other lipid metabolism related factors in children with primary nephrotic syndrome |
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| HAO Sheng,HE Wei-xun,ZHU Guang-hua,TIAN Guo-li,WU Ying. Adiponectin and other lipid metabolism related factors in children with primary nephrotic syndrome[J]. The Journal of Clinical Pediatrics, 2011, 29(4). DOI: 10.3969/j.issn.1000-3606.2011.04.009 |
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| Authors: | HAO Sheng HE Wei-xun ZHU Guang-hua TIAN Guo-li WU Ying |
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| Affiliation: | HAO Sheng,HE Wei-xun,ZHU Guang-hua,TIAN Guo-li,WU Ying(Department of Renal and Rheumatology,Children's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200040,China) |
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| Abstract: | Objective To investigate the level of adiponectin(ADPN)in children with primary nephrotic syndrome(PNS)and the relationships between plasma ADPN and other lipid metabolism related factors.Methods The levels of plasma and urine ADPN were quantitatively measured in 71 patients with PNS in acute stage(acute stage group)and 37 patients with PNS in complete remission(remission stage group)and 35 healthy children(control group).Patients with PNS in acute stage were divided into steroid-responsive group(159 patien... |
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| Keywords: | adiponectin nephrotic syndrome lipid metabolism children |
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