NPY在心血管疾病诊断和治疗中的临床应用

目的：为了研究血浆神经肽Y（NPY）在心血管疾病诊断和治疗中的临床应用。方法：利用放射免疫分析（RIA）检测了180例冠心病（CHD）心力衰竭（Ⅰ级46例,Ⅱ级45例,Ⅲ级48例,Ⅳ级41例）。89例急性心肌梗死（AMI）。167例高血压（58例原发性高血压,109例妊娠高血压综合征）和47例正常对照组的血清NPY水平并做了比较分析。结果：全部患者的血浆NPY明显高于对照组（P〈0.05～0.001）,180例CHD心力衰竭中,41例Ⅳ级心力衰竭血浆NPY明显高于Ⅲ级,Ⅲ级明显高于Ⅱ级,Ⅱ级明显高于Ⅰ级,从而表明随着心力衰竭的严重程度血浆NPY水平亦增高;妊娠高血压综合征血浆NPY的水平与心力衰竭的严重程度的变化一致。结论：血浆NPY是心血管疾病诊断和治疗中的有效指标。

The Clinical Application of Determination of Plasma NPY Levels for Diagnosis and Treatment of Cardiovascular Diseases

Objective To study the clinical usefulness of determination of plasma NPY levels for diagnosis and treatment of cardiovascular disease.Methods Plasma levels of NPY were determind with RIA in 180 patients with heart failure from CHD,89 patients with AMI,58 patients with essential hypertension,109 patients with PIH and 47 controls.Results The plasma levels of NPY in 180 patients with heart failure were 206.37±40.1pg/ml（Ⅰ grade,P0.05）,218.62±64.83pg/ml（Ⅱ grade,P0.05）,269.16±56.57pg/ml（Ⅲ grade,P0.01） and 314.82±56.73pg/ml（Ⅳ grade,P0.001）,respectively.The plasma levels were 345.12±68.71pg/ml and 191.46±38.92pg/ml in patients with AMI and hypertension as a whole,respectively.All these levels were significantly higher than those in controls（P0.05～0.001）.Among the patients,the plasma NPY levels increased along with advance of the disease process.Conclusion Plasma NPY level was a useful marker for diagnosis and treatment of cardiovascular diseases.