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| 双歧杆菌脂磷壁酸对结肠癌细胞Toll样受体表达的影响 | |
| 引用本文： | 王跃 罗强 陈淑惠 刘明方. 双歧杆菌脂磷壁酸对结肠癌细胞Toll样受体表达的影响[J]. 中华微生物学和免疫学杂志, 2005, 25(10): 803-805 |
| 作者姓名： | 王跃 罗强 陈淑惠 刘明方 |
| 作者单位： | 重庆医科大学临床微乍物学教研室,400016 |
| 基金项目： | 重庆市教委科研项目（040308） |
| 摘 要： | 目的通过研究双歧什菌脂磷壁酸（lipoteichoic acid，LTA）对结肠癌细胞中Toll样受体（TLR）表达的影响，探讨TLR在启动双歧杆菌LTA抗肿瘤信号转导通路中的作用。方法用RT-PCR检测结肠癌细胞HCT-116经双歧杆菌LTA处理前后11R的表达变化。结果结肠癌HCT-116细胞有TLR的基础表达，且经LTA处理后受体的表达增强，呈剂量依赖件。结论双歧杆菌LTA可上调TLR的表达，提示双歧杆菌LTA诱导肿瘤细胞凋亡的信号转导途径可能由TLR启动。 |
| 关 键 词： | 脂磷壁酸 双歧杆菌 Toll样受体 表达 |
| 收稿时间： | 2004-11-29 |
| 修稿时间： | 2004-11-29 |
The effect of lipoteichoic acid of Bifidobacterium on Toll-like receptor expression in colon cancer cells |
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| WANG Yue, LUO Qiang, CHEN Shu-hui, LIU Ming-fang.. The effect of lipoteichoic acid of Bifidobacterium on Toll-like receptor expression in colon cancer cells[J]. Chinese Journal of Microbiology and Immunology, 2005, 25(10): 803-805 | |
| Authors: | WANG Yue LUO Qiang CHEN Shu-hui LIU Ming-fang. |
| Affiliation: | Department of Clinical Microbiology, Chongqing University of Medical Science, Chongqing 400016, China |
| Abstract: | Objective To explore the signal transduction pathway of lipoteichoic acid(LTA) of Bifidobacterium in anti-tumor mechanism through investigating the effect of LTA on the expression of Toll-like receptor(TLR) in colon cancer cells.Methods Changes of TLR expression in colon cancer cells HCT-116 treated with LTA was detected by RT-PCR.Results The basic expression of TLR in HCT-116 cells was confirmed,and after treatment with different dose of LTA of Bifidobacterium, the expressions of TLR(especially TLR2) were markedly increased in a dose-dependent manner.Conclusion LTA of Bifidobacterium can upregulate the expression of TLR in HCT-116 cells,it seems that TLR initiates the anti-tumor signal transduction of LTA of Bifidobacterium on apoptosis of colon tumor cells. |
| Keywords: | Lipoteichoic acid Bifidobacterium Toll-like receptor Expression |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |