| IL-8在喉癌及癌边缘组织中的表达及其意义 |
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| 引用本文： | 宋津辉,戴嵩. IL-8在喉癌及癌边缘组织中的表达及其意义[J]. 临床耳鼻咽喉头颈外科杂志, 2002, 16(12): 672-673 |
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| 作者姓名： | 宋津辉 戴嵩 |
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| 作者单位： | 解放军第463医院耳鼻咽喉科,沈阳,110042;解放军第463医院耳鼻咽喉科,沈阳,110042 |
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| 摘 要： | 目的 :探讨IL 8在喉癌及癌边缘组织中的表达及其与喉癌生物学行为的关系。方法 :采用免疫组化SABC方法对 35例原发喉癌及癌边缘 1.0cm组织中的IL 8进行检测。结果 :喉癌组中 2 4例阳性 (6 8.6 % ) ,癌旁组中 15例阳性 (42 .9% ) ,喉癌组与癌旁组阳性率之间差异显著 (P <0 .0 5 ) ;肿瘤发生部位、分化程度及是否有淋巴结转移差异不显著。结论 :提示IL 8在喉癌中可能起着一定的作用 ;其在喉癌中的高表达可能与患者的病程及免疫状态有关。
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| 关 键 词： | 喉肿瘤 白细胞介素-8 免疫组织化学 |
| 文章编号： | 1001-1781(2002)12-0672-02 |
| 修稿时间： | 2002-06-23 |
The expression of IL-8 on laryngeal carcinoma and edge tissues |
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| SONG Jinhui DAI Song. The expression of IL-8 on laryngeal carcinoma and edge tissues[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2002, 16(12): 672-673 |
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| Authors: | SONG Jinhui DAI Song |
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| Affiliation: | Department of Otorhinolaryngology, Hospital of PLA 463, Shenyang 110042. |
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| Abstract: | OBJECTIVE: To explore the expression of IL-8 on laryngeal carcinoma and the edge tissues and its relationship with the character of laryngeal carcinoma. METHOD: Immunohistochemical SABC detections were carried out in 35 case of original laryngeal cancer and the edge tissues (1.0 cm near the tumor). RESULT: The positive rate was 68.6% in 24 case of carcinoma group, 42.9% in 15 case of edge group. The statistical difference between carcinoma group with edge group was very significant(P < 0.05). The expression of IL-8 had no difference in location, tumor developed degree and lymph metastases. CONCLUSION: The expression of IL-8 may play an important role in the process of laryngeal cancer and the patients' immune stage. |
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| Keywords: | Laryngeal neoplasms Interleukin 8 Immunohistochemistry |
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