从EPO信号通路途径探讨"肝藏血,主疏泄"的分子机制

通过对"肝藏血,主疏泄"理论的内涵分析,结合西医学研究结果,提出:所谓"肝藏血"并非由"主疏泄"功能所派生,而应是"肝藏血"是"主疏泄"的物质载体,"主疏泄"功能的体现是"肝藏血"于气机调节、脾胃调节、生殖调节、情志调节等各方面的具体反映,"肝藏血"功能的正常和发挥又赖以"肝主疏泄"功能的正常为前提。首次尝试从促红细胞生成素(EPO)信号通路途径探讨"肝藏血,主疏泄"的分子机制,并得出结论:EPO既与血液生成、调节相关,又兼具抗抑郁等作用,成为中医"肝藏血,主疏泄"的可靠依据。为探讨抑郁症、经前期综合征等情志病证发病机制,提供新的思路。

Discussion on the molecular mechanism of "liver storing blood with controlling dispersion" based on erythropoietin signaling pathway

Based on the connotation analysis of TCM term of "liver storing blood with controlling dispersion" combined with achievement of recent research of western medicine, this article puts forward that "liver storing blood" is not derived from the function of "controlling dispersion", but is the material barrier.The function of "controlling dispersion" reflects in "liver storing blood" in regulation of qi, spleen and stomach, reproduction or emotion, conversely, the normal function of "liver storing blood" relies on the normal function of "controlling dispersion".So this article attempts the first time to discuss the molecular mechanism of "liver storing blood with controlling dispersion" based on erythropoietin (EPO) signaling pathway.The effect of EPO on production or regulation of blood and against depression is the reliable basis for TCM theory of "liver storing blood with controlling dispersion".This study should provide the new idea to explore the mechanism of depression, premenstrual syndrome and other emotional diseases.