北京市体检人群EB病毒联合抗体检测结果分析

目的通过分析3项EB病毒(EBV)抗体联合检测结果,了解体检人群EB病毒感染情况,为鼻咽癌早期筛查提供技术支持。方法选取2017年1月1日—2018年6月30日在北京航天总医院健康管理中心进行EBV(Rta)-IgG、衣壳抗原(VCA)-IgA、早期抗原(EA)-IgA 3种抗体联合检测的体检人员共4251名,采用SPSS 16.0软件进行统计分析。结果4251名受检者中3种EBV抗体单项阳性率的比较差异有统计学意义(χ2=12.465,P=0.000),阳性率由高至低的顺序依次为VCA-IgA、EA-IgA、Rta-IgG;不同性别间VCA-IgA阳性率男性高于女性(P=0.000);不同年龄组3种EBV抗体阳性率总体随年龄增长而增高,EA-IgA(P=0.000)及Rta-IgG(P=0.0038)在不同年龄组中阳性率有显著差异,在61岁以上的受检者中EA-IgA和Rta-IgG阳性率最高,分别为6.3%及3.7%,VCA-IgA在51岁以上的受检者中阳性率最高;92.9%的受检者3项检测均为阴性,1项阳性者占6.4%,2项阳性者占0.7%,未发现3项阳性者;抗体阳性检测结果男性与女性聚集情况比较无差别,抗体检出阳性受检者在耳鼻喉科检查发现鼻炎、鼻窦炎及其他异常比例较高。结论3种EBV抗体的阳性率与性别和年龄都有一定的关系,50岁以上的人群应作为重点筛查对象。EBV抗体联合检测阳性受检者推荐鼻咽镜检查,为鼻咽癌的早期筛查提供依据。

Analysis on the results of Epstein-Barr virus antibody combined determination in healthy subjects of Beijing

Objective To analyze the results of 3 Epstein-Barr virus(EBV)antibody combined determination,to evaluate the status of EBV infection among healthy subjects,and to provide a reference for the early screening of nasopharyngeal carcinoma.Methods A total of 4251 healthy subjects from the Health Management Center of Beijing Aerospace General Hospital from January 1,2017 to June 30,2018 were enrolled.EBV Rta-IgG,viral capsid antigen(VCA)-IgA and early antigen(EA)-IgA antibodies were determined combinedly.The results were analyzed statistically by SPSS 16.0 software.Results Among the 4251 healthy subjects,there was statistical significance in the single positive rates of 3 EBV antibodies(χ2=12.465,P=0.000),and the positive rates were in the order of VCA-IgA,EA-IgA and Rta-IgG antibodies from high to low.The positive rate of VCAIgA antibody in males was higher than that in females(P=0.000).The overall positive rate of 3 EBV antibodies increased with ages.The positive rates of EA-IgA antibody(P=0.000)and Rta-IgG antibody(P=0.0038)had statistical significance in different age groups.The positive rates of EA-IgA and Rta-IgG antibodies were high in subjects≥61 years old(6.3%and 3.7%,respectively),and the positive rate of VCA-IgA antibody was the highest in subjects≥51 years old.Among the subjects,92.9%were triple-negative,6.4%were single-positive,0.7%were double-positive,and no tirple-positive was found.The results of antibody positivity showed no difference in the aggregation of males and females,and the proportions of rhinitis,sinusitis and other abnormalities were higher in antibody positive group.Conclusions The positive rates of 3 EBV antibodies are related to sex and age.Subjects≥50 years old should focus on EBV antibody screening.Nasopharyngoscopy should be recommended for patients with positive EBV antibodies,in order to provide a reference for the early screening of nasopharyngeal carcinoma.