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血清CD27和CD27L的检测在胃癌中的临床意义
引用本文:刘涛,袁建明,沈建康,郁骁珩,王天翔. 血清CD27和CD27L的检测在胃癌中的临床意义[J]. 首都医药, 2011, 0(10): 26-28
作者姓名:刘涛  袁建明  沈建康  郁骁珩  王天翔
作者单位:上海交通大学医学院附属瑞金医院卢湾分院,200020
摘    要:目的探讨胃癌患者血清CD27和CD27L的表达与胃癌及病理指标的关系。方法应用ELISA方法检测42例胃癌患者血清标本中CD27和CD27L的表达,与40例同期正常对照者的血清标本作对比分析。同时采用单因素方差分析和Spearman相关分析探寻CD27和CD27L的表达浓度与胃癌病理类型、病理分期及TNM分期的关系。结果胃癌患者血清CD27和CD27L的表达显著低于正常对照者(P<0.05)。在胃癌患者中,除血清CD27L的表达在病理分期Ⅱ期和Ⅲ期之间(P=0.017)有显著差异以及血清CD27的表达在N1和N2之间(P=0.022)有显著差异外,其余指标在不同病理类型、分期及TNM分期之间无显著差异。Spearman相关分析显示,CD27和CD27L的表达与病理类型、分期及TNM分期无显著相关性。结论血清CD27和CD27L表达与胃癌的发病密切相关,可作为协同判断胃癌发病的指标。

关 键 词:CD27  CD27L  检测  胃癌

The clinical significance of detection of serum CD27 and CD27L in gastric carcinoma
Abstract:Objective To investigate the expressions of CD27 and CD27L,and the relations with pathological indexes of gastric carcinoma.Methods The expressions of serum CD27 and CD27L from 42 patients with gastric carcinoma were detected with ELISA and compared with serum samples from 40 healthy controls.ANOVA and Spearman correlation were used to investigate the relationship between the expressions of CD27 and CD27L and pathological types,pathological staging and TNM staging.Results The expressions of CD27 and CD27L were significantly lower in patients with gastric carcinoma than in healthy controls.In patients with gastric carcinoma,except for the expression of CD27L between pathological stage Ⅱand Ⅲ(P=0.017)and the expression of CD27 between N1 and N2(P=0.022),no other significant difference existed in pathological type,staging and TNM staging.Spearman correlation showed no significant relationship between expressions of CD27 and CD27L and pathological type,staging and TNM staging.Conclusions The expressions of CD27 and CD27L,which can be used as collaborative indicators,are closely related to development of gastric carcinoma.
Keywords:CD27  CD27L
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