| Effect of Chengzai Pill on the L-Type Ca^2＋ Channel Currents of Osteoblasts Pretreated with Methylprednisolone |
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| 引用本文： | 陈燕平,贾丙申,黄克勤,张文杰,薛延,周重光,张万强,王友京. Effect of Chengzai Pill on the L-Type Ca^2＋ Channel Currents of Osteoblasts Pretreated with Methylprednisolone[J]. 中医杂志(英文版), 2007, 27(4): 293-298 |
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| 作者姓名： | 陈燕平 贾丙申 黄克勤 张文杰 薛延 周重光 张万强 王友京 |
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| 摘 要： | Objective: To observe the effect of the serum containing Chengzai Pill on the L-type voltage-sensitive calcium channels current (L-VSCCsC) of osteoblastic MC3T3-E1 cells pretreated with methylprednisolone (mPSL). Methods: A control group, a model group, a low dose group and a high dose group were set up. The whole cell patch clamp technique was used to record L-VSCCsC of 10 osteoblastic MC3T3-E1 cells in each group and their peak currents were determined. Results: The peak current of the control group was 0.2284±0.0209 nA; the peak current of the model group was 0.1839±0.0179 nA; decreased by 19.5% as compared with the control group (P<0.01); the peak current of the low and high dose groups was 0.2526± 0.0093 nA and 0.2671±0.0120 nA respectively, increased by 37.4% and 45.2% as compared with the model group (P<0.01); the difference between the low and high dose groups was P<0.05. Conclusion: 1. mPSL inhibits L-VSCCsC of osteoblasts; and 2. The serum containing Chengzai Pill increases L-VSCCsC of osteoblasts pretreated with mPSL.
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| 关 键 词： | 成骨细胞 钙离子通道 甲强龙 膜片钳 |
Effect of Chengzai Pill on the L-Type Ca2+ Channel Currents of Osteoblasts Pretreated with Methylprednisolone |
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| Chen Yanping,Jia Bingshen,Huang Keqin,Zhang Wenjie,Xue Yan,Zhou Chongguang,Zhang Wanqiang,Wang Youjing. Effect of Chengzai Pill on the L-Type Ca2+ Channel Currents of Osteoblasts Pretreated with Methylprednisolone[J]. Journal of Traditional Chinese Medicine, 2007, 27(4): 293-298 |
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| Authors: | Chen Yanping Jia Bingshen Huang Keqin Zhang Wenjie Xue Yan Zhou Chongguang Zhang Wanqiang Wang Youjing |
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| Affiliation: | Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China. |
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| Abstract: | OBJECTIVE: To observe the effect of the serum containing Chengzai Pill on the L-type voltage-sensitive calcium channels current (L-VSCCsC) of osteoblastic MC3T3-E1 cells pretreated with methylprednisolone (mPSL). METHODS: A control group, a model group, a low dose group and a high dose group were set up. The whole cell patch clamp technique was used to record L-VSCCsC of 10 osteoblastic MC3T3-E1 cells in each group and their peak currents were determined. RESULTS: The peak current of the control group was 0.2284 +/- 0.0209 nA; the peak current of the model group was 0.1839 +/- 0.0179 nA; decreased by 19.5% as compared with the control group (P<0.01); the peak current of the low and high dose groups was 0.2526 +/- 0.0093 nA and 0.2671 +/- 0.0120 nA respectively, increased by 37.4% and 45.2% as compared with the model group (P<0.01); the difference between the low and high dose groups was P<0.05. CONCLUSION: 1. mPSL inhibits L-VSCCsC of osteoblasts; and 2. The serum containing Chengzai Pill increases L-VSCCsC of osteoblasts pretreated with mPSL. |
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| Keywords: | Patch clamp Ca2 channel Chengzai Pill methylprednisolone osteoblast |
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