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女性压力性尿失禁与神经-肌肉疲劳关系的研究
引用本文:陆芝英(综述),华克勤(审校). 女性压力性尿失禁与神经-肌肉疲劳关系的研究[J]. 国外医学:妇产科学分册, 2009, 36(1): 50-52
作者姓名:陆芝英(综述)  华克勤(审校)
作者单位:复旦大学附属妇产科医院;
摘    要:
压力性尿失禁(SUI)是女性常见病,神经-肌肉疲劳可能是其主要发病机制之一。应力状态下,尿道和盆底的横纹肌在维持尿道内压中起重要作用,骨骼肌运动易产生神经-肌肉疲劳。能源物质消耗、代谢产物积聚、神经-肌肉接点失衡引起骨骼肌外周性疲劳,中枢神经系统递质5-羟色胺(5-HT)、多巴胺(DA)和去甲肾上腺素(NA)等是导致中枢性疲劳的主要神经生物学因素,并从中枢性疲劳探讨度洛西汀治疗SUI的机制和疗效欠佳的原因,指明NA可能是SUI药物治疗的新研究方向。

关 键 词:压力性尿失禁  机制  疲劳  神经递质

The Relationship Between Nerve-muscle Fatigue and Stress Urinary Incontinence in Women
LU Zhi-ying,HUA Ke-qin.Fudan university,Obstetric , Gynecology Hospital,Shanghai ,China. The Relationship Between Nerve-muscle Fatigue and Stress Urinary Incontinence in Women[J]. Foreign Medical Sciences(Obstet Gynecol Fascicle), 2009, 36(1): 50-52
Authors:LU Zhi-ying  HUA Ke-qin.Fudan university  Obstetric    Gynecology Hospital  Shanghai   China
Affiliation:LU Zhi-ying,HUA Ke-qin.Fudan university,Obstetric , Gynecology Hospital,Shanghai 200011,China
Abstract:
The periurethral and pelvic striated muscles are the main regulators of urinary continence.These muscles produce an elevation in urethral pressure which allows the maintenance of a positive urethral-bladder pressure gradient during stress.Since all skeletal muscles are affected by neuromuscular fatigue,it can be hypothesized that nerve-muscle fatigue may play a role in the pathophysiology of stress urinary incontinence(SUI)in women.Energetic Materials consumption,metabolite accumulation and neuromuscular ju...
Keywords:Stress urinary incontinence  Mechanism  Fatigue  Neurotransmitter  
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