No pathogenic mutations in the beta-synuclein gene in Parkinson's disease. |
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Authors: | S Lincoln R Crook M C Chartier-Harlin K Gwinn-Hardy M Baker V Mouroux F Richard E Becquet P Amouyel A Destée J Hardy M Farrer |
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Institution: | Mayo Clinic Jacksonville, FL 32224, USA. lincoln.sarah@mayo.edu |
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Abstract: | We present 11 families consistent with autosomal dominant inheritance of probable Parkinson's disease (PD). Although excluded as a cause of disease in these kindreds, mutations in the alpha-synuclein gene have been implicated in familial PD. The beta-synuclein gene is highly homologous, expressed in the nervous system and thus is a good candidate gene for PD. Multipoint linkage analysis was either equivocal or excluded 5q35 haplotype sharing among affected family members. Sequencing the translated exons of the beta-synuclein gene failed to identify any pathogenic mutation. |
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