临床控制的哮喘患者小气道功能和呼出气 NO 水平测定的临床意义简

目的 检测临床控制的哮喘患者小气道功能和呼出气一氧化氮（NO）的水平,探讨其临床意义.方法 对38例临床控制的哮喘患者做肺功能及呼出气NO浓度测定.选择22例初诊哮喘患者和20例健康者作为对照组.结果 38例临床控制哮喘患者中,小气道功能异常22例（57.9%）,正常16例（42.1%）,呼出气NO浓度为（30.42±25.35） ppb,显著低于初诊哮喘组[（80.28±45.62） ppb,P〈0.01],但显著高于健康对照组[（16.15±11.23） ppb,P〈0.01].小气道功能异常哮喘患者呼出气NO浓度为（42.29±23.12） ppb,显著高于小气道功能正常患者呼出气NO浓度[（20.54±10.12） ppb,P〈0.01].结论临床控制的哮喘患者小气道功能异常可能与气道炎症持续存在有关,测定患者小气道功能和呼出气NO浓度有助于指导哮喘治疗.

Clinical significance of small airway function and fractional exhaled nitric oxide measurement in patients with clinically controlled asthma

Objective To investigate the significance of small airway function and fractional exhaled nitric oxide concentration in patients with clinically controlled asthma. Methods 38 patients with clinically controlled asthma were selected in the study. Lung function was performed and the concentrations of fractional exhaled nitric ox- ide were measured. 22 patients with asthma who were newly diagnosed and 20 healthy subjects were selected as the controls. Results In the 38 patients with clinically controlled asthma, there were 22 cases （57.9%） of abnormal small airway function. The level of fractional exhaled nitric oxide was 30.42 ± 25.35 ppb in patients with clinically controlled asthma, which was lower than that in patients with asthma who were newly diagnosed （ 80. 28 ± 45.62 ppb）, （P 〈0. 01 ）, but significantly higher than that in the healthy controls （ 16. 15 ± 11.23 ppb） （P 〈0. 01 ）. The level of fractional exhaled nitric oxide was obviously higher in patients with clinically controlled asthma than in the controls （P 〈 0. 01 ）. Conclusion Abnormal small airway function and airway inflammation persistently exist in pa- tients with clinically controlled asthma, and the detection of small airway function and fractional exhaled nitric oxide may provide guidances for the treatment of asthma.