胸腔灌注洛铂与顺铂治疗肺癌性胸腔积液的疗效和护理

目的观察胸腔灌注洛铂(LBP)与顺铂(DDP)治疗肺癌性胸腔积液的疗效、毒副反应及护理。方法 60例确诊为肺癌性胸腔积液的患者,经胸腔置管引流术排尽积液后,随机分为LBP组和DDP组,每组30例。胸腔内灌注治疗,比较各组的疗效、患者的生活质量和毒副反应。结果 LBP组有效率为86.7%,DDP组有效率为63.3%(P0.05)。LBP组消化道不良反应发生率为20.0%,DDP组消化道不良反应发生率为46.7%(P0.05)。LBP组的Kamofsky评分较DDP组有显著提高(P0.05)。结论 LBP胸腔灌注治疗肺癌性胸腔积液疗效肯定,良好的护理是治疗成功的关键。

Effect and nursing care of lobaplatin and cisplatin in the treatment of pleural perfusion in patients with lung cancer

Objective To observe the effect and adverse reactions and nursing care of lobaplatin （LBP） and cisplatin （DDP） in the treatment of pleural perfusion in patients with lung cancer. Methods 60 lung cancer patients with pleural effusion after chest drainage were randomly divided into two groups according pathological types： 30 cases in the LBP group （Group A） and 30 cases in the DDP group （Group B）. The therapeutic effect, 1ife quality and toxic side effects were evaluated. Results The response rate was 86.7% and 63.3% respectively in the group A and B （P〈0.05）. The rate of gastrointestinal side effect was 20.0% and 46.7% respectively in the group A and B （P〈0.05）. The Karnofsky scores of the group A were higher than that in the group B （P〈0.05）. Conclusion The intracavity injection of LBP is more effective in the treatment of malignant pleural effusion. The better nursing care is the key factor for successful treatment.