骨髓间充质干细胞移植在肝再生中的应用

随着当今医学的发展,干细胞的应用逐渐涉及到各个领域,并发挥着无限的潜能。干细胞以其自我更新及多向分化的能力可以对多种疾病进行替代治疗。肝病终末期肝细胞数量减少,肝功能衰竭,通过干细胞的替代治疗,肝功能能够得以改善,肝纤维化得到缓解甚至逆转。干细胞治疗成为有望替代肝移植的新技术。此文就干细胞在肝病治疗中的潜能作一综述,包括干细胞的来源、治疗机制、治疗途径,并对其临床应用进行探讨。

The application of bone marrow mesenchymal stem cells transplantation in liver regeneration

With the development of modern medicine,stem cells with unlimited potential was gradually involved in various fields.The ability of self-renewal and multidirectional differentiation can offer replacement treatment for multiple diseases.In the end-stage of liver disease,with the reduction of liver cells and failure of liver function,liver function can be improved and liver fibrosis can be slowed or even reversed through the replacement therapy of stem cell.Stem cell therapy is expected to be the new technology for the replacement of liver transplantation.This review summarizes the general understanding of the therapeutic potentials of stem cells in liver disease,including the sources,mechanisms,and threapy methods of hepatic stem cells,and discusses some challenges for their therapeutic application.