| 反向激动剂的药理效应特征 |
| |
| 引用本文： | 张厚利,唐泽耀,杨静娴,林原.反向激动剂的药理效应特征[J].中国药理学通报,2005,21(11):1285-1288. |
| |
| 作者姓名： | 张厚利 唐泽耀 杨静娴 林原 |
| |
| 作者单位： | 大连医科大学药理学教研室,辽宁,大连,116027 |
| |
| 摘 要： | 反向激动剂指一种新分类概念。与阻断激动剂效应的拮抗剂不同,反向激动剂产生的效应与激动剂相反。本文介绍了作用于H2受体,H3受体,μ-阿片受体,肾上腺素能β-受体,5-羟色胺受体反向激动剂的作用特征。反向激动剂有良好的临床应用前景。
|
| 关 键 词： | 反向激动剂 激动剂 拮抗剂 |
| 文章编号： | 1001-1978（2005）11-1285-04 |
| 收稿时间： | 2005-07-18 |
| 修稿时间： | 2005-08-08 |
Characteristics of inverse agonist action |
| |
| ZHANG Hou-li,TANG Ze-yao,YANG Jing-xian,LIN Yuan.Characteristics of inverse agonist action[J].Chinese Pharmacological Bulletin,2005,21(11):1285-1288. |
| |
| Authors: | ZHANG Hou-li TANG Ze-yao YANG Jing-xian LIN Yuan |
| |
| Institution: | Dept of Pharmacology, Dalian Medical University, Dalian 116027, China |
| |
| Abstract: | Inverse agonist is a new type of classification.Different form antagonist that blocks the effect of agonist,inverse agonist produces opposite effect to that of agonist.The characteristics of inverse agonists acting on different receptors including H_2,H_3,μ opioid,adrenergic β, and 5-HT_((1B)) receptors are discussed in this paper.Recent investigation suggested that inverse agonist has potential clinical application. |
| |
| Keywords: | inverse agonist agonist antagonist |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
