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| 酒石酸托特罗定的合成研究 | |
| 引用本文： | 王景阳,黄淑云,张增均. 酒石酸托特罗定的合成研究[J]. 天津药学, 2006, 18(5): 71-73 |
| 作者姓名： | 王景阳 黄淑云 张增均 |
| 作者单位： | 天津药物研究院,天津,300193 |
| 摘 要： | 目的:合成酒石酸托特罗定并进行工艺改进。方法:以对甲苯酚为起始原料,经缩合、甲基化、还原、酯化、胺化、脱甲基化、拆分、精制等反应合成酒石酸托特罗定,并对脱甲基化反应进行了工艺改进。结果:通过改进工艺,总收率由9.23%提高到13.5%。结论:优化工艺后,收率提高,成本降低,解决了劳动保护和环保问题,更适合工业化生产。 |
| 关 键 词： | 酒石酸托特罗定 合成工艺 毒蕈碱受体拮抗剂 |
| 文章编号： | 1006-5687（2006）05-0071-03 |
| 收稿时间： | 2006-06-30 |
| 修稿时间： | 2006-06-30 |
Synthesis of tolterodine L-tartrate |
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| Wang Jingyang,Huang Shuyun,Zhang zengjun. Synthesis of tolterodine L-tartrate[J]. Tianjin Pharmacy, 2006, 18(5): 71-73 | |
| Authors: | Wang Jingyang Huang Shuyun Zhang zengjun |
| Affiliation: | Tianjin Institute of Pharmaceutical Reserch, Tianjin 300193 |
| Abstract: | Object: To synthesis tolterodine L-tartrate and improve the synthetic technology.Methods: Tolterodine was synthesized through the condensation,methylation,reduction,esterification,ammoniation,demethylation,sepration from the stating material p-methylphenol.The condition of demethylation was improved.Results: The overall yield increased from 9.23% to 13.5% with improved technology.Conclusion: The improved technology with higher overall yield and lower costs was more suitable for industry production. |
| Keywords: | tartrate tolterodine synthesis antimuscarinic agent |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |