| 浅谈定心胶囊中丹参酚酸B的含量测定 |
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| 引用本文： | 王丹,张艳,张军,刘晓蕾. 浅谈定心胶囊中丹参酚酸B的含量测定[J]. 中国医疗前沿, 2011, 0(2): 79-80 |
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| 作者姓名： | 王丹 张艳 张军 刘晓蕾 |
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| 作者单位： | 辽宁中医药大学附属医院;辽宁中医药大学;沈阳市急救中心; |
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| 摘 要： | 目的以高效液相色谱法测定定心胶囊中有效成分之一丹参酚酸B的含量,以明确其作用机理。方法采用Hypersil ODS（5μ,4.6mm×200mm）色谱柱,甲醇-乙腈-甲酸-水（30：10：1：59）为流动相,检测波长286nm。结果丹参酚酸B在0.1024μg～0.6146μg范围内呈良好的线性关系,r=0.9999;平均回收率为96.66%（n=9）,RSD=0.9%。结论所建立的方法稳定、可靠,可为该产品建立质量控制方法提供参考。
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| 关 键 词： | 定心胶囊 高效液相色谱法 丹参酚酸B |
Measurement of Salvianolic-acid B in Dingxin Capsule |
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| WANG Dan,ZHANG Yan,ZHANG Jun,et al.. Measurement of Salvianolic-acid B in Dingxin Capsule[J]. China Healthcare Innovation, 2011, 0(2): 79-80 |
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| Authors: | WANG Dan ZHANG Yan ZHANG Jun et al. |
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| Affiliation: | WANG Dan,ZHANG Yan,ZHANG Jun,et al.Subsidiary hospital of Liaoning university of traditional Chinese medicine,shenyang110032,China |
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| Abstract: | Objective To explore the mechanism of Dingxin Capsule by determining one of the effective ingredients（Salvianolic acid B）.Methods Chromatography was set of Hypersil ODS（5μ,4.6mm×200mm）,mobile phase：MeOH-CAN-Hac-H2O（3010159,V/V）,with gradient elution,wavelength tested was 286nm.Results The methodological study showed that a good linear correlation existed in the range of 0.1024-0.6146μg of the Salvianolic-acid B applied,r=0.9999.The average recovery was 96.66%（n=9） with the RSD of 0.9%.Conclusion The method is simple,reproducible and accurate to the quality control for Funing Suppository. |
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| Keywords: | Dingxin Capsule High Performance Liquid Chromatography Salvianolic acid B |
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