| 不同时期肝硬变患者4种血管活性物质的测定 |
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| 引用本文： | 周新民,许其增.不同时期肝硬变患者4种血管活性物质的测定[J].解放军医学杂志,1992,17(4):278-281. |
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| 作者姓名： | 周新民 许其增 |
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| 作者单位： | 南京军区福州总医院，南京军区福州总医院，上海长征医院，南京军区福州总医院，南京军区福州总医院，南京军区福州总医院 西安西京医院 |
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| 摘 要： |
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| 关 键 词： | 肝硬变 前列腺素E2 血栓素B2 |
DETERMINATIONS OF FOUR VASOACTIVE SUBSTANCES IN CIRRHOTIC PATIENTS IN DIFFERENT STAGES |
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| Zhou Xinmin,Xu Qizeng,Li Shi,Gao Heyuan,Chen Zhihang,Liu Ying. Fuzhou General Hospital of Nanjing Command,PLA,Fuzhou.DETERMINATIONS OF FOUR VASOACTIVE SUBSTANCES IN CIRRHOTIC PATIENTS IN DIFFERENT STAGES[J].Medical Journal of Chinese People's Liberation Army,1992,17(4):278-281. |
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| Authors: | Zhou Xinmin Xu Qizeng Li Shi Gao Heyuan Chen Zhihang Liu Ying Fuzhou General Hospital of Nanjing Command PLA Fuzhou |
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| Abstract: | Urinary excretion of prostaglandin E2. (PGE2) and thromboxane B2 (TXB2, a stable metabolite of TXA2), atrial natriuretic peptide (ANP) and arginine vasopressin (AVP) in plasma were determined with radioimmunoassay in 30 healthy normal controls (NC) and 53 cirrhotic patients without asoites (n = 18), with ascites (n = 25) and with hepatorenal syndrome (HRS, n=10). All of four vasoactive substances in the group of cirrhotic patients without ascites were significantly higher than that in NG (P<0.05~0.001). With the worsening of cirrhosis, the excretion of PGE2 decreased while the excretion of TXB2 increased progressively; plasma ANP level showed no change, but plasma AVP level decreased markly even to normal. These data indicate that the derangement of renal hemodynamics and sodium-water homeostasis are present before ascites formation in cirrhosis, and the imbalance of four vasoactive substances is an important factor in enhancing sodium-water retention and development of HRS. |
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| Keywords: | Liver cirrhosis Prostaglandin E2 Thromboxane B2 Atrial natriuretic peptide Arginine vasopressin |
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