| 珍香胶囊治疗子宫内膜异位症作用机制的初步研究 |
| |
| 引用本文： | LUO Li-li,曾如辉,SUI Xu-xia,傅玉才. 珍香胶囊治疗子宫内膜异位症作用机制的初步研究[J]. 中国现代医学杂志, 2008, 18(14) |
| |
| 作者姓名： | LUO Li-li 曾如辉 SUI Xu-xia 傅玉才 |
| |
| 作者单位： | 1. 汕头大学医学院第一附属医院,妇科,广东,汕头,515041
2. 汕头大学医学院,细胞衰老实验室,广东,汕头,515041 |
| |
| 基金项目： | 国家中医药管理局中医药科学技术研究基金 , 广东省自然科学基金 , 广东省科技厅科技计划 |
| |
| 摘 要： | 目的探索中药珍香胶囊治疗大鼠子宫内膜异位症的机制。方法采用自体子宫移植方法建立大鼠子宫内膜异位症模型。4周后，将大鼠随机分组进行药物治疗（珍香胶囊组、内美通组、空白对照组）。治疗4周后，免疫组化方法检测大鼠异位内膜组织的雌激素（ER）α和β受体、血管内皮生长因子（VEGF）、芳香化酶（Aromatase）。ELISA方法检测大鼠血清、腹腔液中白介素（IL）-6、VEGF、肿瘤坏死因子（TNF）α。结果疗效：珍香胶囊能够抑制、破坏异位内膜的增长，其作用与内美通相似。ER—α、ERβ、VEGF、IL-6、Afomatase在对照组及各用药组大鼠的移植组织中均有表达，各组之间无明显差异（P〉0．05）；ELISA检测各组大鼠血清、腹腔液中VEGF、IL-6、TNF—α水平，均未见阳性表达。结论珍香胶囊治疗大鼠子宫内膜异位症可能并不影响异位病灶组织的雌激素受体、血管内皮生长因子、芳香化酶，不影响大鼠血液、腹腔液的各种因子，其确切治疗机制目前尚不清楚。
|
| 关 键 词： | 子宫内膜异位症 大鼠 珍香胶囊 内美通 酶联免疫吸附试验 免疫组织化学试验 |
Primary study on mechanism of treating endometriosis with Zhenxiang capsule |
| |
| LUO Li-li,ZENG Ru-hui,SUI Xu-xia,FU Yu-cai. Primary study on mechanism of treating endometriosis with Zhenxiang capsule[J]. China Journal of Modern Medicine, 2008, 18(14) |
| |
| Authors: | LUO Li-li ZENG Ru-hui SUI Xu-xia FU Yu-cai |
| |
| Affiliation: | 1.Department of Gyneclolgy;The First Affiliated Hospital of Shantou University Medical College;Shantou;Guangdong 515041;P.R.China;2.Laboratory of Cellular Senescence;Shantou University Medical College;P.R.China |
| |
| Abstract: | [Objective] To explore the mechanism of treating endometriosis with Zhenxiang capsule. [Methods] Rat endometriosis models were produced by autotransplantation with uterine tissues. 4 weeks after the autotransplantation, rats were divided randomly into three groups. One was treated with Zhenxiang capsule through intragastric administration every day for the four consecutive weeks. Nemestran and saline solution were taken as positive and negative controls respectively. The expressions of estrogen receptor (ER... |
| |
| Keywords: | endometriosis rat models Zhenxiang capsule Nemestran ELISA immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
