| 人参茎叶皂甙对狗心脏血流动力学的影响 |
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| 引用本文： | 潘文军,张宝凤,吴春福,王利彦,陈山,谭毓治.人参茎叶皂甙对狗心脏血流动力学的影响[J].沈阳药科大学学报,1985(1). |
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| 作者姓名： | 潘文军 张宝凤 吴春福 王利彦 陈山 谭毓治 |
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| 作者单位： | 沈阳药学院药理教研室，沈阳药学院药理教研室，沈阳药学院药理教研室，沈阳药学院药理教研室，沈阳药学院药理教研室，江西中医药研究所 |
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| 摘 要： | 实验表明人参茎叶皂甙(GSL)50mg/kg i.v.可使狗左室泵功能和心肌收缩性发生程度不同的改变,可使 LVP,CO,CI,TPVR,BP,HR,耗氧量,(dp/dt)max,(dp/dt)/CPIP等下降,PF,SI,t-(dp/dt)max 等上升。这些结果与目前掌握的人参根总皂甙对狗血流动力学的影响基本一致。
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| 关 键 词： | 人参茎叶皂甙 血流动力学 时间—张力指数 |
EFFECT OF GINSENG SAPONIN OF LEAF AND STEM ON CARDIAC PERFORMANCE AND HEMODYNAMICS OF DOGS |
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| Pan Wenjun Zhang Baofeng Wu Chunfu Wang Liyan Chen San Tan Yuzhi.EFFECT OF GINSENG SAPONIN OF LEAF AND STEM ON CARDIAC PERFORMANCE AND HEMODYNAMICS OF DOGS[J].Journal of Shenyang Pharmaceutical University,1985(1). |
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| Authors: | Pan Wenjun Zhang Baofeng Wu Chunfu Wang Liyan Chen San Tan Yuzhi |
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| Institution: | Pan Wenjun Zhang Baofeng Wu Chunfu Wang Liyan Chen San Tan Yuzhi* Department of Pharmacology *Jiangxi Institute of Chinese Materia Medica |
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| Abstract: | In 7 open chest anesthetized mongrel dogs LVP,dp/dt,CO,ECG were recor- ded on an RM-46 4-channel polygraph.The saponin extrcted from the leaves and stems of ginseng(Panax ginseng C.A.Meyer),IV 50 mg/kg,caused a significant decrease in BP,LVP,and HR,but no significant alternation in contractility and pump function of heart as shown by(dp/dt)/CPIP and CI,respectively.As a result of HR slowing and LVP reduction,tension-tlme index was reduced,which suggested that the myocardial oxygen consumption was declined(P<0.05)or(P< 0.01),t-(dp/dt)max was elevated remarkably.The results also showed that the parameters of TPVR,CO as well as PF,SI and(dp/dt)max were not markedly altered. |
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| Keywords: | GSL Hemodynamics Tension-time index |
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