| 消痰散结方对裸鼠胃肿瘤中ICAM-1表达的影响 |
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| 引用本文： | 王建平,魏品康,许玲. 消痰散结方对裸鼠胃肿瘤中ICAM-1表达的影响[J]. 辽宁中医杂志, 2001, 28(8): 498-499 |
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| 作者姓名： | 王建平 魏品康 许玲 |
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| 作者单位： | 第二军医大学长征医院中医科,;第二军医大学长征医院中医科,;第二军医大学长征医院中医科, |
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| 摘 要： | 观察消痰散结方对裸鼠胃癌组织中胃癌细胞粘附分子ICAM 1表达的影响。建立裸鼠MKN 4 5人胃癌模型 ,采用免疫组化S P法检测胃癌组织中ICAM 1的表达。结果 ,中药组胃癌组织中ICAM 1表达水平明显低于空白对照组。说明 ,消痰散结方抑制胃癌细胞转移的环节可能与影响粘附分子的表达 ,进而影响细胞的粘附性机制有关。
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| 关 键 词： | 消痰散结方 胃肿瘤 细胞间粘附分子 |
| 文章编号： | 1000-1719(2001)08-0498-02 |
| 修稿时间： | 2001-02-10 |
Effect of Xiaotan Sanjie Recipe on Expression of ICAM-1 in Gastric Carcinoma |
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| WANG Jian-ping,WEI Pin-kang,XU Ling. Effect of Xiaotan Sanjie Recipe on Expression of ICAM-1 in Gastric Carcinoma[J]. Liaoning Journal of Traditional Chinese Medicine, 2001, 28(8): 498-499 |
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| Authors: | WANG Jian-ping WEI Pin-kang XU Ling |
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| Abstract: | Objective:To investigate effect of Xiaotan Sanjie Recipe on expression of ICAM-1 in Gastric Carcinoma.Methods:A transplantable ascites tumor model of MKN-45 human gastric carcinoma in nude mice was established,by using S-P immunohistochemical method with anti-ICAM-1 monoclonal antibody,the expression of ICAM-1 in Gastric Carcinoma was studied.Results:The expression of ICAM-1 in Gastric Carcinoma in Chinese medicine group was obviously lower than that in control group.Conclusions:By lowering expression of ICAM-1 in Gastric Carcinomatous cell with Xiaotan Sanjie Recipe,mechanism of adhension of gastric carcinomatous cell was affected. |
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| Keywords: | Xiaotan Sanjie Recipe gastric carcinoma ICAM-1 |
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