| 硒对辐射所致过氧化脂质含量及谷胱甘肽过氧化物酶活性的影响 |
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| 引用本文： | 郭英,冯彪,隋志仁.硒对辐射所致过氧化脂质含量及谷胱甘肽过氧化物酶活性的影响[J].营养学报,1992(3). |
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| 作者姓名： | 郭英 冯彪 隋志仁 |
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| 作者单位： | 白求恩医科大学营养教研室，白求恩医科大学营养教研室，白求恩医科大学营养教研室 长春 130021，长春 130021，长春 130021 |
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| 摘 要： | 以肝、脾组织中过氧化脂质(LPO)含量及谷胱甘肽过氧化物酶(GSHL-Px)活性为指标探讨硒的辐射防护效应。实验结果表明:BALB/C纯系雄性小鼠经3Gy ~(60)Co γ射线照射后3天,肝、脾组织LPO生成量比未照射者均显著增多,而GSH-Px活性却都显著降低;但于照射前连续7天每日经口灌胃亚硒酸钠溶液0.2ml(含硒12.5μg)的实验组动物,肝、脾组织LPO含量均明显少于照射对照组,而GSH-Px活性都显著高于照射对照组,结果提示,通过降低LPO含量和增加GSH-Px活性,硒对小鼠可能有辐射防护作用。
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| 关 键 词： | 硒 过氧化脂质 谷胱甘肽过氧化物酶 辐射损伤 |
THE EFFECT OF SELENIUM ON LPO LEVEL AND GSH-Px ACTIVITY OF TISSUES IN IRRADIATED MICE |
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| Guo Ying,Feng Biao,Sui Ztiren.THE EFFECT OF SELENIUM ON LPO LEVEL AND GSH-Px ACTIVITY OF TISSUES IN IRRADIATED MICE[J].Acta Nutrimenta Sinica,1992(3). |
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| Authors: | Guo Ying Feng Biao Sui Ztiren |
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| Abstract: | The protective effect of selenium against irradiation were studied by measuring the content of lipid peroxide (LPO) and activity of glutathione peroxidase (GSH-Px) in liver and spleen of BALB/C mice. The results showed that LPO contents in liver and spleen of whole-body-irradiated mice were higher than those of the control group on the third day after irradiation with 3 Gy 60Co γ-ray, while the GSH-Px activity of these tissues was significantly decreased. However, when the animals were given sodium selenite solution 0.2ml (12.5μg selenium) per day via mouth successively for 7 days before irradiation, there were remarkably reduced LPO level and increased GSH-Px activity in liver and spleen of irradiated mice. It is suggested that selenium supplementation may prevent mice from radiation injury by reducing LPO level and increasing GSH-Px activity in liver and spleen. |
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| Keywords: | selenium lipid peroxide glutathione peroxidase radiation damage |
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