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Synthetic peptides including acidic clusters as substrates of yeast casein kinase-2 |
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| Authors: | ORIANO MARIN ANDREA CALDERAN PAOLO RUZZA GIANFRANCO BORIN FLAVIO MEGGIO NIKODEM GRANKOWSKI FERNANDO MARCHIORI |
| Abstract: | The synthesis is reported of a series of glutamyl peptide analogs of the model substrate H-Ser-Glu-Glu-Glu-Glu-Glu-OH of casein kinase-2 (CK-2). A convenient HPLC method for the separation of slightly different acidic peptides is also reported. The site specificity of yeast casein kinase-2 (Y-CK2) is examined with the aid of synthesized peptide substrates. |
| Keywords: | casein kinase-2 glutamyl peptides peptide substrates |