|
|||||
|
|
| 海洋真菌095407的抗菌活性代谢产物的研究 | |
| 引用本文： | 崔海滨,梅文莉,韩壮,吴娇,林海鹏,洪葵,戴好富. 海洋真菌095407的抗菌活性代谢产物的研究[J]. 中国药物化学杂志, 2008, 18(2): 131-134 |
| 作者姓名： | 崔海滨 梅文莉 韩壮 吴娇 林海鹏 洪葵 戴好富 |
| 作者单位： | 1. 汕头大学,海洋生物研究所,广东,汕头,515063;中国热带农业科学院,热带生物技术研究所,海南,海口,571101 2. 中国热带农业科学院,热带生物技术研究所,海南,海口,571101 |
| 基金项目： | 国家重点基础研究发展计划(973计划)前期研究专项基金 , 科技部科研院所社会公益研究专项基金 |
| 摘 要： | 目的对海洋真菌095407的抗菌活性成分进行研究。方法用多种色谱技术对化合物进行分离纯化，用光谱技术和理化性质鉴定化合物的结构，并用滤纸片琼脂扩散法测定化合物的抗耐甲氧西林金黄色葡萄球菌和白色念珠菌活性。结果从095407号真菌发酵液提取物中分离得到4个化合物，分别鉴定为3，4，5-三甲基-1，2-苯二酚（1）、decarboxydihydrocitrinone（2）、甘露醇（3）、刺芒柄花素（4）。结论化合物1为首次以天然产物的形式分离得到，活性测试结果表明化合物1和2具有抗耐甲氧西林金黄色葡萄球菌活性。 |
| 关 键 词： | 海洋真菌 化学成分 结构鉴定 抗菌活性 |
| 文章编号： | 1005-0108(2008)02-0131-04 |
| 收稿时间： | 2007-07-20 |
| 修稿时间： | 2007-07-20 |
Antibacterial metabolites from the fermentation broth of marine fungus 095407 |
|
| CUI Hai-bin,MEI Wen-li,HAN Zhuang,WU Jiao,LIN Hai-peng,HONG Kui,DAI Hao-fu. Antibacterial metabolites from the fermentation broth of marine fungus 095407[J]. Chinese Journal of Medicinal Chemistry, 2008, 18(2): 131-134 | |
| Authors: | CUI Hai-bin MEI Wen-li HAN Zhuang WU Jiao LIN Hai-peng HONG Kui DAI Hao-fu |
| Affiliation: | (1. Marine Biology Institute, Science Center, Shantou University, Shantou 515063, China; 2. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China) |
| Abstract: | Aim To study the antibacterial constituents from marine fungus 095407. Methods The secondary metabolites were isolated and purified by column chromatography, and their structures were identified by physicochemical and spectral data. Their antibacterial activities were tested against methicillin-resistant Staphylococcus aureus (MRSA ) and Candida albicans by paper disco diffusion method. Results Four compounds were isolated from the broth of marine fungus 095407, and their structures were elucidated as 3,4,5-trimethyl-1,2-benzenediol (1), decarboxydihydrocitrinone (2), mannitol (3), and formononetin (4). Conclusion Compound 1 was a new natural product, Compounds 1 and 2 showed inhibitory effect on MRSA. |
| Keywords: | marine fungus chemical constituent structural identification antibacterial activity |
| 本文献已被 维普 万方数据 等数据库收录！ | |
| 点击此处可从《中国药物化学杂志》浏览原始摘要信息 | |
| 点击此处可从《中国药物化学杂志》下载全文 | |