| Graves病与人类MHC-DR基因的关联研究 |
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| 引用本文： | 曹峰林,禹宏,吴丽杰,申秀玲. Graves病与人类MHC-DR基因的关联研究[J]. 中国地方病防治杂志, 2006, 21(1): 14-15 |
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| 作者姓名： | 曹峰林 禹宏 吴丽杰 申秀玲 |
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| 作者单位： | 哈尔滨医科大学第一临床医院,哈尔滨 150011 |
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| 摘 要： | 目的探讨弥漫性甲状腺肿伴甲亢(GD)与北方汉族人MHC-DR基因多态性的相关性。方法采用聚合酶链式反应和顺序特异性引物(PCR-SSP)基因分析方法,对31例GD患者及30例无血缘关系的健康人的人类主要组织相容性复合体(MHC-Ⅱ类)DR各等位基因及亚基因进行检测分析,并将该方法与其它检测MHC-Ⅱ类基因的方法进行了比较研究。结果(1)MHC-DRB1*0301(RR=4.28P<0.01)基因与GD病呈正相关;(2)其它MHC-DRB1*其它各等位基因未见异常。结论MHC-DRB1*0301基因可能为北方汉族人GD病的致病易感基因,尽管目前基因分型方法已有多种,但本文所采用的方法(PCR-SSP)具有快速、简便、敏感、准确和可靠等优点,值得推广应用。
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| 关 键 词： | 聚合酶链式反应(PCR)序/列特异性引 弥漫性甲状腺肿病伴甲亢 易感基因 |
| 文章编号： | 1001-1889（2006）01-0014-02 |
| 收稿时间： | 2005-09-28 |
| 修稿时间： | 2005-09-28 |
MHC-DRB1 * gene polymorphism in patients with Graves disease |
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| CAO Feng-lin, YU Hong, WU Li-jie. MHC-DRB1 * gene polymorphism in patients with Graves disease[J]. Chinese Journal of Control of Endemic Disenaces, 2006, 21(1): 14-15 |
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| Authors: | CAO Feng-lin YU Hong WU Li-jie |
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| Affiliation: | Department of Cardiology, Harbin First Hospital Harbin 150011, China |
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| Abstract: | Objective In order to study the correlativity between MHC-DRB1*gene polymorphism and Graves disease(GD).Methods MHCDRB1*gene Polymorphism in 31patients with GD and 30 normal control subjects was analyzed by using the polymerease chain reaction/sequence specific primer(PCR/SSP)technique.Result The frequency of MHC-DRB1*0301 allele was significantly higher in patients than that in the controls,RR of GD patients was 4.28,P<0.01.Conclusion These findings further verify that immunogenetics play a predominant pathogenetics role in a subset of GD patients.Individuals carrying MHC-DRB1*0301 alleles maybe susceptibility gene to GD.This method is more specific,sensitive,simple,rapid and accurate,and could be applied to the routine clinical detection. |
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| Keywords: | MHC-DRB1*Genes Graves disease Susceptibility gene |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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