阿地白介素致嗜酸粒细胞增多症

1例62岁女性2型糖尿病患者因反复出现低血糖入院。血常规检查:嗜酸粒细胞计数和百分比分别为1.72×109/L、25.4%,诊断为嗜酸粒细胞增多症。追问病史,患者因胃窦癌根治术后给予阿地白介素,皮下注射200万U/次,隔日1次,持续4个月余。阿地白介素治疗期间,患者的嗜酸粒细胞计数与百分比逐渐升高如下:第3天,0.02×109/L、2.3%;第11天,0.33×109/L、7.4%;第26天,3.07×109/L、38.7%;第34天,4.21×109/L、47.1%。嗜酸粒细胞升高,考虑与阿地白介素相关。停用阿地白介素,2周后嗜酸粒细胞计数恢复正常。

Eosinophilia due to aldesleukin

A 62-year-old woman with type 2 diabetic mellitus was hospitalized with relapsing hypoglycemia.Routine blood tests showed that her eosinophil count and percentage were 1.72×10^9/L and 25.4%,respectively.Eosinophilia was diagnosed.A review of her medical history revealed that she had received SC aldesleukin 200 million units once every other day for 4 months and more after undergoing radical operation for cancer of the gastric antrum.During the treatment of aldesleukin,her eosinophil counts and percentages were gradually increasing as follows： on day 3,0.02 × 10^9/L and 2.3%;on day 11,0.33 × 10^9/L and 7.4%;on day 26,3.07 × 10^9/L and 38.7%;on day 34,4.21 × 10^9/L and 47.1%.Eosinophilia was considered to be related to aldesleukin.Aldesleukin was discontinued and,two weeks later,her eosinophil count returned to normal range.