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| 胸水中CYFRA21－1测定的临床意义 | |
| 引用本文： | 于方治,吴京,沈馨. 胸水中CYFRA21－1测定的临床意义[J]. 上海医学检验杂志, 1996, 0(4) |
| 作者姓名： | 于方治 吴京 沈馨 |
| 作者单位： | 上海市胸科医院 |
| 摘 要： | 利用ＢｏｅｈｒｉｎｇｅｒＭａｎｎｈｅｉｍ公司的ＣＹＦＲＡ２１－１酶免疫分析试剂盒，测定了已有明确诊断的１３０例胸腔渗漏液标本。结果表明，ＣＹＦＲＡ２１－１对于癌性胸水的诊断敏感性为６１．３％，特异性为８７．３％，准确度为７２．３％。若同时利用ＡＤＡ活性测定排除结核性胸膜炎，则其特异性可达９２．８％。揭示ＣＹＦＲＡ２１－１测定对胸水良恶性的诊断与鉴别诊断具有重要的临床价值。 |
| 关 键 词： | CYFRA21－1；细胞角质素（Cytokeratin）；肺癌（Lungcancer）；胸水（Pleuraleffusion）；腺苷脱氨酶（Adenosinedeaminase，ADA） |
Preliminary evaluation of CYFRA 21-1 assay in pleural effusion diagnosis |
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| Yu Fang-zhi,Wu Jing,Shen Xin.. Preliminary evaluation of CYFRA 21-1 assay in pleural effusion diagnosis[J]. Shanghai Journal of Medical Laboratory Sciences, 1996, 0(4) | |
| Authors: | Yu Fang-zhi Wu Jing Shen Xin. |
| Abstract: | The values of cytokeratin 19 fragment(CYFRA 21-1)and adenosine deaminase(ADA) were measured in the pleural fluid of 75 patients with lung cancer, 43 with tuberculous pleurisy,and 12 with benign diseases other than tuberculosis.CYFRA 21-1 levels in malignant effusions were significantly higher than those in benign effusions.For malignant effusions the diagnostic sensitivity of CYFRA 21-1 is 61.3% , specificity is 87. 3% and diagnostic accuracy is 72. 3% ,On the other hand ,the mean ADA activity in tuberculous effusion was significantly higher than that resulting from other causes of pleural effusion. It is suggested that the combined use of these two assays is an useful tool for the diagnosis of malignant effusions. |
| Keywords: | CYFRA 21-1 Cytokeratin Lung cancer Pleural effusion Adenosine deaminase |
| 本文献已被 CNKI 等数据库收录！ | |