应用小鼠在Y形迷宫中的自主选择能力测定急性及慢性东莨菪碱与吗啡对记忆的影响

应用Ｙ型迷宫研究了急性与慢性东莨菪碱和吗啡对小鼠记忆能力的影响。单剂量东莨菪碱（１ｍｇ／ｋｇｉｐ）和吗啡（１０ｍｇ／ｋｇｉｐ）均能显著损害小鼠的短时记忆（ｗｏｒｋｉｎｇｍｅｍｏｒｙ）。重复给药后东莨菪碱的这种作用很快消失。但吗啡每天一次，连续３次给药这种作用加强，连续５次给药这种作用反而减弱。东莨菪碱不能损害小鼠长时记忆（ｒｅｆｅｒｅｎｃｅｍｅｍｏｒｙ），而吗啡对长时记忆有损害作用。结果还提示小鼠短时记忆不受自发活动能力的影响。

Effects of Acute and Chronic Scopolamine and Morphine on Memory in Mice Using a Y-maze Spontaneous Alternation Task

The acute and chronic effects of scopolamine and morphine on memory were assesed using a Y-maze spontaneous alternation task in mice. Single dose of scopolamine(1mg/kg ip) or morphine(10 mg/kg ip) significantly impaired working memory.With repeated doses,this effect of scopolamine diminished very rapidly. However following 3 doses of morphine,this effect was enhanced,after 5 repeated doses,it did not exert significant effects.Scopolamine did not disrupt reference memory,while morphine produced reference memory impairment. Experimental data also suggested that spontaneous alternation performance and locomotor activity were independent behaviors.