新型餐后血糖调节剂——格列奈类药物的研究进展

早期相胰岛素分泌能力的损害是引起2型糖尿病及其并发症的重要因素，格列奈类药物作为一种新型促胰岛素分泌的药物，起效快，作用时间短，较磺酰脲类能更好地控制餐时血糖的增高，降低餐后血糖高峰，与双胍类合用可以发挥协同效应。其安全性良好，极少发生餐后低血糖，并能预防糖尿病的心血管并发症等。本文就早期相胰岛素分泌与糖尿病的关系、格列奈类药物的药理特性及临床应用等作一概述。

Novel postprandial hypoglycemic drugs——theprogress of research on glinides

The impairment of the ability of early phase of insulin secretion is an important factor of type 2 diabetes and its complications Glinides represent a new rapid onset and short duration insulin secreting agents that ameliorate postprandial hyperglycemia by improving insulin secretory dynamics to a normal level more effectively than sulfonylureas and appear particularly useful in combination with metformin The drug, which demonstrates limited risk of hypoglycemia, is safe for use and can prevent cardiovascular disease of diabetes mellitus and its complications This article is to sum up the relationship between early phase of insulin secretion and diabetes mellitus, the pharmacological properties and clinical application of glinides.