On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid |
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| Authors: | U. Mengs |
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| Affiliation: | 1. Department of Pathology and Toxicology, Dr. Madaus & Co., Ostmerheimer Strasse 198, D-5000, K?ln 91, Federal Republic of Germany
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| Abstract: | ![]()
The histopathogenesis of rat forestomach carcinoma induced experimentally with aristolochic acid was investigated. The intragastric administration of 10 mg/kg/day caused extensive necrosis of the squamous epithelium, followed by regeneration and hyperplasia, papilloma formation and ultimately by invasive squamous cell carcinoma. |
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