淫羊藿甙对小鼠主要器官结构和功能的影响研究

目的 以淫羊藿甙（ICA）为供试药物,研究其对小鼠主要器官结构和功能的影响.方法 100只6周龄健康雌性SPF级昆明系小鼠随机分为两组,分别灌服ICA和生理盐水,在试验第0、1、4、7、10、13、16、19天采血取血清,进行血清生化指标（AST、ALT、ALP、LDH）的检测；剖杀后取心、肝、肺、肾进行组织学观察.结果 ICA对小鼠血清生化指标具有一定的调节作用,表现为使血清中AST和ALT水平升高,降低血清中的ALP和LDH水平,但组织学观察则未见异常.结论 ICA对小鼠主要器官功能与组织结构影响较小.

Development effect of icariin on the structure and function of mouse main organs

Objective In order to research the development effect of icariin on the structure and function of mouse main organs. Methods 100 6-week-old female mice were divided into two groups randomly and fed with icariin and saline solution, at 0, 1st, 4th, 7th, 10th, 13th, 16th and 19th day, we measured the level of AST, ALT, ALP and LDH in serum by reagent-box, and the histological change of heart, liver, lung and kidney were observed. Result Icariin can condition the biochemical indicator of main organ obviously, increase the levels of AST and ALT in serum, decrease the levels of ALP and LDH in serum, but there is no change in organizational structure of main organs. Conclusion Icariin can affect the function of main organs but don＇ t change its structure.