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| 亮菌甲素速溶片剂的研制及其利胆作用研究 | |
| 引用本文： | 朱家壁,栾立标,史群昌. 亮菌甲素速溶片剂的研制及其利胆作用研究[J]. 药学学报, 1992, 0(3) |
| 作者姓名： | 朱家壁 栾立标 史群昌 |
| 作者单位： | 中国药科大学药剂研究室，中国药科大学药剂研究室，中国药科大学药剂研究室 南京 210009，南京 210009，南京 210009 |
| 摘 要： | 试制出亮菌甲素速溶片剂(A),并以市售品亮菌甲素片剂(B)、亮菌甲素粉针(C)等作对照,考察了它们对大鼠体内胆汁分泌作用的影响,并测定了A和B的体外溶出速率。结果表明,A片剂比B片剂明显地增强了利胆作用,A片的体外溶出速率也较B片为快。 |
| 关 键 词： | 亮菌甲素 利胆作用 |
DEVELOPMENT OF RAPID-DISSOLUTION ARMILLARISIN-A TABLET AND STUDY ON ITS CHOLERETIC ACTION IN RATS |
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| JB Zhu,LB Luan,QC Shi Division of Pharmaceutics,China Pharmaceutical University,Nanjing. DEVELOPMENT OF RAPID-DISSOLUTION ARMILLARISIN-A TABLET AND STUDY ON ITS CHOLERETIC ACTION IN RATS[J]. Acta pharmaceutica Sinica, 1992, 0(3) | |
| Authors: | JB Zhu LB Luan QC Shi Division of Pharmaceutics China Pharmaceutical University Nanjing |
| Affiliation: | JB Zhu,LB Luan,QC Shi Division of Pharmaceutics,China Pharmaceutical University,Nanjing 210009 |
| Abstract: | For increasing the choleretic action of armillarision-A, a newformulation of rapid- dissolution tablet (A) was developed. The effect of A, a marketedamillarisin- A tablet (B) and a armillarisin- A Na sterile power (C) on rats biliation invivowere investigated. The dissolution rates of A and B were also determined. The resultsdemonstrate that the choleretic action of A is equal to C but superior to B, and the disso-lution rate of A is higher than B. Moreover, the armillafisin-A dissolved percentage of Ain vitro at time t was well correlated with the biliation net accumulative amount in vivo attime 3t. |
| Keywords: | Armillarisin--A Choleretic |
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