多发性硬化免疫调节细胞的变化及与疾病复发的关系

目的观察复发与缓解期多发性硬化患者免疫调节细胞(CD4+CD25+细胞及Th2细胞)的变化及与疾病复发的关系.方法用流式细胞仪分别对复发期(n=26)及缓解期(n=22)MS患者的外周血标本进行CD4+CD25+细胞及Th2细胞的百分数进行检测,并与疾病复发进行相关性比较.结果复发期与缓解期CD4+CD25+细胞及Th2细胞均少于正常对照标本;而CD4+CD25-细胞及Th1细胞与对照标本比较无统计学意义的差异.CD4+CD25+细胞及Th2细胞的数量与疾病复发具有良好的相关性(P值分别等于0.000及0.003).结论MS患者在复发期与缓解期均存在有免疫调节细胞数量减少,免疫调节细胞的减少程度与疾病复发具有良好的相关性.

Abnormal of regulatory T cells and its relationship with disease relapse in MS patients

Objective To observe reguktory T cells (CD4+ CD25+ cells and Th2 cells) of MS patients at the time of rekpse and remission, and its relationship with disease relapse in clinical. Methods CD4+ CD25+ cells and Th2 cells in MS patients were detected by flow cytometry at the timepoints of rekpse (n = 26) and remission (n = 22). Associativity between the detecting results and disease rekpse was compared. Results The percentages of CD4+ CD25+ cells and Th2 cells in MS patients at the timepoints of rekpse and remission were lower than those in normal control. CD4+ CD25- cells and Th1 cells had no significant difference between MS group and control group. The percentage of CD4+ CD25+ cells and Th2 cells had a good relationship with rekpse (P = 0.000 and P = 0.003, respectively). Conclusion The reguktory T cells of MS patients are deciesed at timrpionts of rekpse and remission, which is perfectly associated with rekpse in clinical.