| G显带法验证FISH分析X射线工作者染色体易位畸变 |
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| 引用本文： | 孙元明,李进,王芹,唐卫生,王知权.G显带法验证FISH分析X射线工作者染色体易位畸变[J].中国辐射卫生,2002,11(1):5-6. |
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| 作者姓名： | 孙元明 李进 王芹 唐卫生 王知权 |
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| 作者单位： | 中国医学科学院中国协和医科大学放射医学研究所,天津,300192 |
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| 摘 要： | 目的 FISH是分析染色体畸变的有效方法。该方法的准确性受多种因素影响。用G显带方法验证FISH对早先X射线工作者染色体易位分析。方法 对X射线工作者同时采用两种方法分析染色体易位，进行统计学分析比较。结果 两种方法分析染色体易位率有很好相关性。结论 FISH方法是分析X射线工作者染色体易位率进行剂量重建的可行方法。
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| 关 键 词： | 荧光原位杂交 G显带 X射线工作者 染色体畸变 |
| 文章编号： | 1004-714X(2002)01-0005-01 |
| 修稿时间： | 2001年5月14日 |
Experimental Observation of G Banding Verifying X- ray Workers' Chromosome Translocation Detected by FISH |
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| SUN Yuan-ming,LI Jin,WANG Qin,et al..Experimental Observation of G Banding Verifying X- ray Workers'' Chromosome Translocation Detected by FISH[J].Chinese Journal of Radiological Health,2002,11(1):5-6. |
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| Authors: | SUN Yuan-ming LI Jin WANG Qin |
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| Institution: | SUN Yuan-ming,LI Jin,WANG Qin,et al.Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300192,China. |
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| Abstract: | Objective FISH is the most effective way of detecting chromosome aberration and many factors affect its accuracy.G-banding is used to verify the results of early X-ray workers'chromosome translocation examined by FISH.Methods The chromosome translocations of early X-ray workers have been analysed by FISH(fluorescence in situ hybridization)and G-banding,yields of translocation treated with statistics.Results The chromosome aberrations frequencies by tow methods are closely related.Conclusion FISH is a feasible way to analyse chromosome aberrations of X-ray workers and reconstruct dose. |
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| Keywords: | FISH G-banding X-ray Worker Chromosome Aberration |
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