miR-101在宫颈癌组织中的表达及其临床意义

目的:探讨miR-101在宫颈癌组织中的表达及与宫颈癌临床病理特征的关系。方法:应用逆转录实时荧光定量聚合酶链反应(RT-PCR)检测40例宫颈癌组织miR-101水平,以30例子宫肌瘤患者作为正常对照,探讨其表达与宫颈癌临床病理特征的关系。结果:与正常宫颈组织比较,miR-101在宫颈癌组织中表达下调(0.54±0.32)倍,差异有统计学意义(P<0.05)。不同病理分级、间质浸润深度、淋巴结转移宫颈癌患者miR-101表达水平分别比较差异均具有统计学意义(P<0.05),而不同年龄、临床分期、肿瘤直径、绝经与否的宫颈癌患者miR-101表达水平分别比较差异均无统计学意义(P>0.05)。结论:miR-101的表达与宫颈癌的发生、转移和侵袭能力有关,可作为治疗及评价预后的参考指标,并可为肿瘤靶向治疗提供新靶点。

Expression of miR-101 in cervical cancer tissue and its clinical significance

Objective:To explore the expression level of miR-101 in cervical cancer tissue and its relationship with clinicopathological features of cervical cancer.Methods:RT-PCR was used to detect the expression level of miR-101 in 40 cases with cervical cancer,30 cases with hysteromyoma were selected as normal control group,the relationship between miR-101 expression and clinicopathological features of cervical cancer was analyzed.Results:Compared with normal control group,the expression level of miR-101 in cervical cancer group decreased by(0.54±0.32) times,there was significant difference(P<0.05).There was significant difference in the expression level of miR-101 among the cases with cervical cancer of different pathological grades,depths of interstitial infiltration,and lymph node metastasis or not(P<0.05),but there was no significant difference in the expression level of miR-101 among the cases with different ages,clinical stages,diameters of tumor,menopause or not(P>0.05).Conclusion:The expression of miR-101 is correlated with the occurrence,metastasis,and invasive ability of cervical cancer,and miR-101 can be used as a reference index for treatment and predicting prognosis,which can provide a new target for targeted therapy of cervical cancer.