聚乳酸接枝丙烯酰胺制备抗菌材料

采用自由基接枝聚合法，以过氧化苯甲酰为引发剂，制备聚乳酸接枝丙烯酰胺共聚物；对接枝共聚物进行氯化，制备表面含卤胺基团的抗菌聚乳酸高分子材料。考察了丙烯酰胺含量、引发剂浓度、聚合温度、聚合时间等对接枝率的影响。采用核磁共振氢谱、红外光谱等对接枝聚合物的分子结构进行了表征；利用溶液浇铸法，制备抗菌聚乳酸薄膜，并对薄膜的抗菌性能等进行了研究。结果表明：实验获得的卤胺接枝聚乳酸对大肠杆菌抗菌性能明显。

Preparation of Antimicrobial Materials via Graft Polymerization of Polylactic Acid with Acrylamide

Polylactic acid-g-polyacrylamide(PLA-g-PAM) was synthesized via graft polymerization of polylactic acid with acrylamide using benzoyl peroxide (BPO) as initiator, and the medium polymer was treated with sodium hypochlorite to obtain acyclic N-halamines polymer. Influences of polymerization condition on the graft polymerization were investigated. Molecular structures were characterized via 1H-NMR and FT-IR. PLA films were prepared using solution casting method. Results show that the acyclic N-halamines PLA film can provide potent antimicrobial functions against Escherichia coli.