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| 正交设计法优化硝酸益康唑的合成工艺 | |
| 引用本文： | 邵律成,陈红,王小燕,何邦平,吕加国,盛春泉. 正交设计法优化硝酸益康唑的合成工艺[J]. 药学实践杂志, 2007, 25(2): 102-103 |
| 作者姓名： | 邵律成 陈红 王小燕 何邦平 吕加国 盛春泉 |
| 作者单位： | 1. 第二军医大学研究生管理大队,上海,200433 2. 第二军医大学药学院,上海,200433 |
| 基金项目： | 致谢：感谢第二军医大学药学本科04级全体学员为本研究所做的工作. |
| 摘 要： | 目的:优化抗真菌药物硝酸益康唑的合成工艺。方法:采用正交设计法,重点考察反应温度、催化剂、反应时间及溶剂四个因素对收率的影响。结果:溶剂对反应收率的影响最为显著,其次是反应时间和催化剂。结论:新工艺原料价廉易得,反应条件温和,后处理简便,收率高。 |
| 关 键 词： | 正交设计 益康唑 合成 |
| 文章编号： | 1006-0111(2007)02-0102-02 |
| 收稿时间： | 2006-08-30 |
| 修稿时间： | 2006-08-30 |
Optimization of the synthesis of econazole nitrate by orthogonal experimental design |
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| SHAO LV-cheng,CHEN Hong,WANG Xiao-yan,HE Bang-ping,LV Jia-guo and SHENG Chun-quan. Optimization of the synthesis of econazole nitrate by orthogonal experimental design[J]. The Journal of Pharmaceutical Practice, 2007, 25(2): 102-103 | |
| Authors: | SHAO LV-cheng CHEN Hong WANG Xiao-yan HE Bang-ping LV Jia-guo SHENG Chun-quan |
| Affiliation: | 1. Graduate Administration Division, Second Military Medical University, Shanghai, 200433, China; 2. School of Pharmacy, Second Military Medical University, Shanghai, 200433, China |
| Abstract: | Objective:To optimize the synthesis of econazole nitrate,a useful antifungal agent.Methods:Orthogonal experimen- tal design is used and the influence of temperature,catalyst,reaction time and solvent on the yield is investigated.Results:Solvent is more important than reaction time and catalyst.Conclusion:The new method has several advantages such as cheap reactants,facile reaction condition,convenient operation and high yield. |
| Keywords: | orthogonal experimental design econazole nitrate synthesis |
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