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Gastroenterology in developing countries: Issues and advances
作者单位:Kate L Mandeville(Centre for Infectious Diseases Epidemiology, Department of Primary Care and Population Sciences, University College London, Hampstead Campus,Royal Free Hospital, London NW3 2PF, United Kingdom);Justus Krabshuis(Highland Data, Les Charleix, 24390 Tourtoirac, Dordogne, France);Nimzing Gwamzhi Ladep(Department of Medicine, University of Jos and Jos University Teaching Hospital, Jos, Plateau State,P.M.B. 2076, Nigeria);Chris JJ Mulder(Department of Gastroenterology, VU University Medical Center, Amsterdam 1081 HV, Holland);Eamonn MM Quigley(World Gastroenterology Organisation and Department of Medicine, National University of Ireland,Cork University Hospital Clinical Sciences Building Wilton,Cork, Ireland);Shahid A Khan(epartment of Hepatology and Gastroenterology, Faculty of Medicine, Imperial College London, St Mary's Campus, London W2 1NY, United Kingdom)  
基金项目:The NIHR Biomedical Research Centre funding scheme,the Higher Education Funding Council for England,the British Liver Trust and the Alan Morement Memorial Fund AMMF
摘    要:
Developing countries shoulder a considerable burden of gastroenterological disease. Infectious diseases in particular cause enormous morbidity and mortality. Diseases which afflict both western and developing countries are often seen in more florid forms in poorer countries. Innovative techniques continuously improve and update gastroenterological practice. However, advances in diagnosis and treatment which are commonplace in the West, have yet to reach many developing countries. Clinical guidelines, based on these advances and collated in resource-rich environments, lose their relevance outside these settings. In this two-part review, we first highlight the global burden of gastroenterological disease in three major areas: diarrhoeal diseases, hepatitis B, and Helicobacter pylori. Recent progress in their management is explored, with consideration of future solutions. The second part of the review focuses on the delivery of clinical services in developing countries. Inadequate numbers of healthcare workers hamper efforts to combat gastroenterological disease. Reasons for this shortage are examined, along with possibilities for increased specialist training. Endoscopy services, the mainstay of gastroenterology in the West, are in their infancy in many developing countries. The challenges faced by those se~ing up a service are illustrated by the example of a Nigerian endoscopy unit. Finally, we highlight the limited scope of many clinical guidelines produced in western countries. Guidelines which take account of resource limitations in the form of "cascades" are advocated in order to make these guidelines truly global. Recognition of the different working conditions facing practitioners worldwide is an important step towards narrowing the gap between gastroenterology in rich and poor countries.

关 键 词:发展中国家  胃肠病  传染性疾病  预防措施
收稿时间:2009-02-03

Gastroenterology in developing countries: Issues and advances
Kate L Mandeville,Justus Krabshuis,Nimzing Gwamzhi Ladep,Chris JJ Mulder,Eamonn MM Quigley,Shahid A Khan. Gastroenterology in developing countries: Issues and advances[J]. World journal of gastroenterology : WJG, 2009, 15(23): 2839-2854. DOI: 10.3748/wjg.15.2839
Authors:Kate L Mandeville  Justus Krabshuis  Nimzing Gwamzhi Ladep  Chris JJ Mulder  Eamonn MM Quigley  Shahid A Khan
Affiliation:Kate L Mandeville;Justus Krabshuis;Nimzing Gwamzhi Ladep;Chris JJ Mulder;Eamonn MM Quigley;Shahid A Khan
Abstract:
Developing countries shoulder a considerable burden of gastroenterological disease. Infectious diseases in particular cause enormous morbidity and mortality. Diseases which afflict both western and developing countries are often seen in more florid forms in poorer countries. Innovative techniques continuously improve and update gastroenterological practice. However, advances in diagnosis and treatment which are commonplace in the West, have yet to reach many developing countries. Clinical guidelines, based on these advances and collated in resource-rich environments, lose their relevance outside these settings. In this two-part review, we first highlight the global burden of gastroenterological disease in three major areas: diarrhoeal diseases, hepatitis B, and Helicobacter pylori. Recent progress in their management is explored, with consideration of future solutions. The second part of the review focuses on the delivery of clinical services in developing countries. Inadequate numbers of healthcare workers hamper efforts to combat gastroenterological disease. Reasons for this shortage are examined, along with possibilities for increased specialist training. Endoscopy services, the mainstay of gastroenterology in the West, are in their infancy in many developing countries. The challenges faced by those setting up a service are illustrated by the example of a Nigerian endoscopy unit. Finally, we highlight the limited scope of many clinical guidelines produced in western countries. Guidelines which take account of resource limitations in the form of "cascades" are advocated in order to make these guidelines truly global. Recognition of the different working conditions facing practitioners worldwide is an important step towards narrowing the gap between gastroenterology in rich and poor countries.
Keywords:Helicobacter pylori  Developing countries  Gastrointestinal diseases  Health care delivery  Practice guidelines
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