Predictors of Refractory Ascites Development in Patients with Hepatitis B Virus-Related Cirrhosis Hospitalized to Control Ascitic Decompensation |
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Authors: | Ju Hee Seo Seung Up Kim Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Sang Hoon Ahn |
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Institution: | 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.;2Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.;3Liver Cirrhosis Clinical Research Center, Seoul, Korea.;4Brain Korea 21 Project for Medical Science, Seoul, Korea. |
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Abstract: | PurposeRefractory ascites (RA) is closely related to a high morbidity and mortality. In this study, we investigated predictors of RA development in patients with hepatitis B virus (HBV)-related cirrhosis who were hospitalized to control ascitic decompensation, and determined predictors for survival in patients who experienced RA.Materials and MethodsWe analyzed 199 consecutive patients with HBV-related cirrhosis who were hospitalized to control ascitic decompensation between January 1996 and December 2008.ResultsMultivariate analyses showed that only serum potassium at admission predicted RA development independently p=0.013; hazard ratio (HR), 2.800; 95% confidence interval (CI), 1.166-6.722]. During the follow-up period, 16 (8.0%) patients experienced RA within 4.2 (range, 1.0-39.2) months after admission for controlling ascitic decompensation, and they survived a median of 8.7 (range, 3.9-51.3) months. Child-Pugh class and RA type were identified as independent prognostic factors affecting the survival in patients with RA (p=0.045; HR, 8.079; 95% CI, 1.231-67.984 and p=0.013; HR, 14.510; 95% CI, 1.771-118.874, respectively).ConclusionSerum potassium was an independent predictor of RA development in patients with HBV-related cirrhosis who were hospitalized to control ascitic decompensation. After RA development, Child-Pugh class and RA type were independent predictors for survival. |
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Keywords: | Ascites chronic hepatitis B cirrhosis predictor refractory survival |
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