缺血性脑血管病患者血管因素与认知功能障碍的关系研究

目的分析缺血性脑血管病患者血管因素与认知功能障碍的相关性。方法我院2014-09—2015-03收治的90例缺血性脑血管病患者为研究对象,并分为轻危组、中危组及高危组,经颅脑多普勒超声测定患者脑血管血流动力学,采取蒙特利尔量表评估患者认知功能,分析缺血性脑血管病患者血管因素与认知功能障碍的关系。结果高危组患者认知功能低于轻危组,以动物命名试验、图形描画、数字交替试验、言语复述、语言流畅、延迟记忆、警觉性、计算力、时间定向等方面评分降低明显;高危组较轻危组及中危组右侧大脑中动脉流速明显上升;3组仅大脑左侧基底动脉平均血流速度对比差异有统计学意义(P0.05);高危组与中危组、轻危组对比,频谱异常率对比差异有统计学意义(P0.05)。结论缺血性脑血管病患者脑血管损伤对患者认知功能可产生严重影响,是造成脑血管病患者出现认知及记忆障碍的相关原因,随着血管危险因素的增多,患者认知功能障碍越明显。

Relationships between vascular factors and cognitive dysfunction in patients with ischemic cerebrovascular dis-ease

Objective To analyze the relationships between vascular factors and cognitive dysfunction in patients with is‐chemic cerebrovascular disease.Methods Ninety patients with ischemic cerebrovascular disease admitted into the hospital from September 2014 to March 2015 were selected and divided into three groups :mild-risk group ,moderate-risk group and high-risk group.The cerebrovascular hemodynamics of each group was calculated by transcranial doppler ultrasound.Cognitive function was assessed by the Montreal Cognitive Assessment Scale ,and the relationships between vascular factors and cognitive impair‐ment were analyzed.Results The cognitive function of the high-risk group that presented less scores of animal naming test , graphic drawing ,digital alternating test ,verbal rehearsal ,language fluency ,delayed memory ,alertness ,computing power ,time orientation and other aspects ,was lower than that of mild-risk group.The flow velocity of the right cerebral artery of the high risk group increased significantly ,compared with that of the mild-risk group and the moderate-risk group;Only the contrast differences in terms of the mean flow velocity in the left side of the brain basilar artery among the three groups were statistical‐ly significant(P<0.05);As for abnormal rate of spectrum ,the statistically significant contrast differences were found when compared the high-risk group with the moderate-risk group and the mild-risk group(P<0.05).Conclusion Cerebrovascular in‐jury may have a serious impact on cognitive function in patients with ischemic cerebrovascular disease ,which may be the related factor that causes cognitive dysfunction.With the increase of vascular risk factors ,the cognitive dysfunction is more obvious .