| 几种静脉输液在输液器中混合时的理化变化 |
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| 引用本文： | 韦曦,崔洁,潘威,张丽,周永丽.几种静脉输液在输液器中混合时的理化变化[J].中国新药杂志,2006,15(23):2052-2054. |
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| 作者姓名： | 韦曦 崔洁 潘威 张丽 周永丽 |
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| 作者单位： | 1. 广西医科大学第五附院 柳州市人民医院,柳州 545001
2. 桂林医学院药学院,桂林,541004 |
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| 摘 要： | 目的：研究几种静脉输液在输液器中混合时发生沉淀的原因，测定其pH值和含量变化。方法：采用紫外分光光度法测定配伍前后药物含量变化；用酸度计测定pH值变化。结果：注射用炎琥宁与维生素B6注射液混合时pH值下降，产生沉淀，含量下降；注射用阿洛西林钠与奥硝唑注射液、硫普乐宁冻干粉针溶媒使用不当配制的输液等酸性药物混合时，pH值下降产生沉淀。结论：炎琥宁与维生素B6注射液、阿洛西林钠与奥硝唑氯化钠注射液等酸性注射剂不可配伍使用。
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| 关 键 词： | 注射用炎琥宁 维生素B6注射液 注射用阿洛西林钠 奥硝唑注射液 注射用硫普罗宁 配伍稳定性 |
| 文章编号： | 1003-3734（2006）23-2052-03 |
| 收稿时间： | 2006-07-10 |
| 修稿时间： | 2006年7月10日 |
Evaluation of several infusions compatibility when mixed |
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| WEI Xi,CUI Jie,PAN Wei,ZHANG Li,ZHOU Yong-li.Evaluation of several infusions compatibility when mixed[J].Chinese Journal of New Drugs,2006,15(23):2052-2054. |
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| Authors: | WEI Xi CUI Jie PAN Wei ZHANG Li ZHOU Yong-li |
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| Abstract: | Objective:To assess the compatibility of several infusion solutions when they were mixed. Methods:A few infusion solutions were competed and then the stability of the drug contents were monitored by ultraviolet spectrophotometry. The changes of pH values were measured by a pH meter. Results:The non-compatibility of Yanhuning for injection with vitamin B6 for injection was found, manifesting the reductions of pH value and Yanhuning concentration as well as the occurrence of precipitation. The combination of azlocillin sodium for injection with omidazole for injection and tiopronin powders for injection led to the unwanted precipitation due to pH values down. Conclusion:The non-compatibility of Yanhuning with vit B6 for injection and azlocillin with omidazole for injection were verified. |
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| Keywords: | Yanhuning for injection viatamin B6 injection azlocillin sodium for injection omidazole and sodium chloride injection tiopronin for injection compatible stability |
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