| 补体因子H和肾上腺髓质素对高糖培养的HBZY-1大鼠系膜细胞的调节作用 |
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| 引用本文： | 耿厚法,鲁一兵,蒋秀琴,李慧敏,许旌,缪珩.补体因子H和肾上腺髓质素对高糖培养的HBZY-1大鼠系膜细胞的调节作用[J].中华内分泌代谢杂志,2008,24(3). |
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| 作者姓名： | 耿厚法 鲁一兵 蒋秀琴 李慧敏 许旌 缪珩 |
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| 作者单位： | 1. 济宁医学院附属医院内分泌科,272029
2. 南京医科大学第二附属医院内分泌科,210011 |
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| 摘 要： | 研究补体因子H和肾上腺髓质素对高糖培养的HBZY-1大鼠系膜细胞转化生长因子β1(TGF-β1)及细胞外基质(ECM)分泌的影响.结果 提示联合应用肾上腺髓质素和补体因子H可显著抑制HBZY-1细胞TGF-β1及ECM的过度分泌而表现出一定的肾脏保护作用.
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| 关 键 词： | 补体因子H 肾上腺髓质素 糖尿病 |
Regulative effect of complement factor H and adrenomedullin on HBZY-1 rat mesangial cells cultured under high glucose concentration |
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| GENG Hou-fa,LU Yi-bing,JIANG Xiu-qin,LI Hui-min,XU jing,MIAO heng.Regulative effect of complement factor H and adrenomedullin on HBZY-1 rat mesangial cells cultured under high glucose concentration[J].Chinese Journal of Endocrinology and Metabolism,2008,24(3). |
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| Authors: | GENG Hou-fa LU Yi-bing JIANG Xiu-qin LI Hui-min XU jing MIAO heng |
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| Abstract: | The renal protective effect of complement factor H(CFH)and adrenomedullin (AM) on rat mesengial ceils (HBZY-1) cultured under high glucose levels was investigated. Results indicated that AM and CFH inhibited the expressions of transforming growth factor-β1 and extracellular matrix in HBZY-1 cells, suggesting that CFH and AM in combination seem to show some renal protective effects on diabetic nephropathy. |
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| Keywords: | Complement factor H Adrenomedullin Diabetes mellitus |
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