| VEGF-A和C在人结肠癌淋巴管生成和淋巴道转移中的作用 |
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| 引用本文： | 陈一凡,;宿菲,;陈明伟,;马晶,;张雅芳,;刘宝全. VEGF-A和C在人结肠癌淋巴管生成和淋巴道转移中的作用[J]. 解剖科学进展, 2014, 0(5): 425-428 |
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| 作者姓名： | 陈一凡, 宿菲, 陈明伟, 马晶, 张雅芳, 刘宝全 |
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| 作者单位： | [1]哈尔滨医科大学解剖学教研室,哈尔滨150081; [2]哈尔滨市第五医院,哈尔滨150040; [3]哈尔滨医科大学生物信息科学与技术学院,哈尔滨150081 |
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| 基金项目： | 黑龙江省自然科学基金资助项目（D200920） |
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| 摘 要： | 目的分析血管内皮生长因子(VEGF)-A和VEGF-C在人结肠癌组织的表达及与结肠癌淋巴管生成和淋巴道转移的关系。方法取人结肠癌组织91例,应用免疫组化方法检测VEGF-A和VEGF-C在结肠癌组织中的表达。应用D2-40标记结肠癌组织的淋巴管,观察结肠癌组织的淋巴管生成情况。结果结肠癌组织中VEGF-A和VEGF-C的表达水平明显高于正常组织,VEGF-A和VEGF-C表达阳性的结肠癌组织的淋巴管密度(LVD)明显高于阴性组织,VEGF-A和VEGF-C的表达及LVD均与淋巴结转移及Duke's分期相关。结论结肠癌组织VEGF-A和VEGF-C过表达与结肠癌的淋巴管生成和淋巴道转移相关。
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| 关 键 词： | 血管内皮生长因子 人结肠癌 淋巴管 转移 |
Role of VEGF-A and VEGF-C in lymphangiogenesis and lymphatic metastasis in human colon cancer |
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| Affiliation: | CHEN Yi-fan, SU Fei, CHEN ZHANG Ya-fang, LIU Bao-quan Ming-wei , MA Jing, ( 1. Department of Anatomy, Harbin Medical University, Harbin 150081; 2. Harbin Fifth Hospital, Harbin 150040; 3. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China ) |
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| Abstract: | Objective To analytic the expressions of VEGF-A and VEGF-C and their association with lymphangiogenesis and lymphatic metastasis in human colon cancer. Methods Ninety one paraffin-embedded specimens from patients with colon cancer were used. The expressions of VEGF-A and VEGF-C were detected by immunohistochemistry. D2-40 was used for detecting lymphangiogenesis in colon cancer. Results The expression level of VEGF-A and VEGF-C was significantly high,~r in .human colon cancer than in normal colon, the density of lymphatic vesseles（LVD） was significantly higher in VEGF-A and VEGF-C positive colon cancer than in VEGF-A and VEGF-C negative colon cancer. The expression level of VEGF-A and VEGF-C and LVD was closely related to lympha node metastasis and Duke＇s stage. Conclusion The overexpresslon of VEGF-A and VEGF-C in colon cancer might be related to the lymphangiogenesis and lymphatic metastasis of colon cancer. |
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| Keywords: | vascular endothelial growt factor human colon cancer lymphatic vessel metastasis |
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